Zuvius Lifesciences Pvt. Ltd.

Ghatkopar, Mumbai, Maharashtra

Pemetrexed disodium heptahydrate has the chemical name L-Glutamine acid, N-[4-[2-(2-amino-4, 7-dihydro-4-oxo1H-pyrrolo[2, 3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate. It is a white to almost-white solid with a molecular formula of C20H19N5Na2O67H2O and a molecular weight of 597.49. The Structural formula is as follows:

Fluorouracil Injection, an antineoplastic antimetabolite, is a sterile, nonpyrogenic injectable solution for intravenous administration. Each mL contains 50 mg fluorouracil in water for injection, pH is adjusted to approximately 9.2 with sodium hydroxide.Chemically, fluorouracil, a fluorinated pyrimidine, is 5-fluoro-2, 4 (1H, 3H)-pyrimidinedione. It is a white to practically white crystalline powder which is sparingly soluble in water. The molecular weight of fluorouracil is 130.08 and the structural formula is:

Oxalipaltin a cell cycle phase monspecific antineoplastic drugs belongs to a new class of platinum agent that contains a platinum atom complexed with oxalate and diaminocyclothexane (dach.).

Leucovorin is one of several active, chemically reduced derivatives of folic acid. It is useful as an antidote to drugs which act as folic acid antagonists.Also known as folinic acid, citrovorum factor, or 5-formyl-5, 6, 7, 8-tetrahydrofolic acid, this compound has the chemical designation of calcium n-[p-[[[(6rs)-2-amino-5-formyl 5, 6, 7, 8-tetrahydo-4-hydroxy-6 pteridinyl]methyl]amino]benzoyl]-l-glutamate (1:1). The structural formula of leucovorin calcium is

Carboplatin injection is supplied as a sterile, aqueous solution available in 50mg5ml, 150mg15ml, 450mg45ml or 600mg60ml multi-dose vials containing 10mgml of carboplatin for administration by intravenous infusion. Each ml contains 10mg carboplatin and water for injection, usp.Carboplatin is a platinum coordination compound that is used as a cancer chemotherapeutic agent. The chemical name for carboplatin is platinum, diammine [1, 1-cyclobutane-dicarboxylato (2-)-0, 0]-, (sp-4-2), and has the following structural formula:

Zuviplat is an anticancer drug of an entirely new category for antitumor activity and low toxicity from among a variety platinum compound developed according to the discovery by barnett rosenberg in the u.s.a that platinum compound inhibit the mitosis of escherichia coli.

Methotrexate (formerly Amethopterin) is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis.Chemically methotrexate is N-[4-[[(2, 4-diamino-6-pteridinyl) methyl]methylamino]benzoyl]-L-glutamic acid

Bleomycin for Injection, USP is a mixture of cytotoxic glycopeptide antibiotics isolated from a strain of Streptomyces verticillus and is freely soluble in water.It is available as a lyophilized powder for intramuscular, intravenous or subcutaneous injection. Each vial contains sterile bleomycin sulfate equivalent to 15 units or 30 units of bleomycin. Sulfuric acid or Sodium hydroxide used, if necessary to adjust the pH.Bleomycins are a group of related basic glycopeptides which differ in the terminal amine substituent of the common structural unit, bleomycin acid. The main components of Bleomycin for Injection are bleomycins A2 and B2. Chemically, bleomycin A2 is N1-[3-(dimethylsulfonio)propyl]-bleomycinamide and bleomycin B2 is N1-[4-(aminoiminomethyl)amino]butyl]-bleomycinamide.The molecular formula of bleomycin A2 is C55H84N17O21S3 and a calculated molecular weight of 1414. The molecular formula of bleomycin B2 is C55H84N20O21S2 and a calculated molecular weight of 1425. The structural formula of bleomycins A2 and B2 are shown below.Note:A unit of bleomycin is equal to the formerly used milligram activity. The term milligram activity is a misnomer and was changed to units to be more precise.

Epirbicin is an anthracycline cytotoxic agent and forma a complex with DNA by interacalation of its planar rings between nucleotide base pairs, with consequent inhibition of nucleic acid (DNA & RNA) and protein synthesis, Such intercalation triggers DNA cleavage by topoisomerase II, resulting in cytocidal activity, Epirubicin also inhibits DNA helicase activity, preventing the enxymatic seperation of double - standard DNA & interfering with replication and transcription. Epirubicin is also involved in oxidationreduction reactions by generating cytotoxic free radicaEpirbicin is an anthracycline cytotoxic agent and forma a complex with DNA by interacalation of its planar rings between nucleotide base pairs, with consequent inhibition of nucleic acid (DNA & RNA) and protein synthesis, Such intercalation triggers DNA cleavage by topoisomerase II, resulting in cytocidal activity, Epirubicin also inhibits DNA helicase activity, preventing the enxymatic seperation of double - standard DNA & interfering with replication and transcription. Epirubicin is also involved in oxidationreduction reactions by generating cytotoxic free radicals.

Gemcitabine HCL is a nucleoside analogue that exhibits antitumor activity.Gemcitabine HCL is 2-deoxy-2, 2- difluorocytidinemonohydrochloride (Beta-isomer).The Structural Formula is as follows:

Zoledronic acid contains a bisphosphonic acid which is an inhibitor of osteoclastic bone resorption. Zoledronic acid is designated chemically as (1Hydroxy-2-imidazol-1-yl-phoshoneothyl) phosphonic acid monohydrate Zoledronic acid is a white crystalline powder. Its molecular formula is C3H10N2O1P2H2O and its molecular weight is 290.1Zoledronic acid injection is available in vials as a sterile lyophilized powder or intravenous infusion. Each vials contains Zoledronic acid monohydrate equivalent to anhydrous Zoledronic acid 4 mg.Inactive Ingredients: Mannitol, IP, Trisodium Citrate dehydrate.

Bortezomib for injection is an antineoplastic agent available for Intravenous Injection (IV) use only.Each single use vials contains 2 mg of bortezomib as a sterile lyophilized powder. Bortezomib id modified dipeptidylboronic acid. The Product is provided as a mannitol boronic ester which, in reconstituted from, consist of the mannitol ester in equilibrium with its chydrolysis product, theMonomeric boronic acid. The substance exits in its cyclic anhydride from as a trimericboroxine.The chemical name for bortezomib, the monomeric boronic acid, is [(1R)-3-methyl-1[(2S)-1-oxo-3-phenyl-222-(pyrazinycarbony) amino]propyl]butyl] boronic acid.

Paclitaxel is a natural product with antitumor activity. Paclitaxel is obtained via a semisynthetic process from Taxusbaccata. The chemical name for paclitaxel is 5B, 20-Epoxy 1, 2 a, 4, 7B, 10 B, 13 a-hexahydroxytax-11-en-9-one 4, 10-diacetate 2-benoate 13-ester with (2R, . 3S)-N-benzoyl-3-phenylisoserine.Paclitaxel has the following structural formula: Paclitaxel is a white to off-white crystalline powder with the empirical formula C47H51 NO14 and a molecular weight of 853.9. It is highly lipophilic, insoluble in water, and melts at around 216-217C.

Zuvitop-100 (etoposide Injection, IP) is a semisynthetic derivative of podophyllotoxin used in the treatment of certain neoplastic diseases. It is 4'-demethylepipodophyllotoxin 9-[4, 6-0-(R)- ethylidence - B-D- glucopyranoside]. It is very soluble in methanol and chloroform, slightly soluble in ethanol, and sparingly soluble in water and ether. It is made more miscible with water by means of organic solvents. It has a molecular weight of 588.58 and a molecular formula of C29 H32 O13.

Docetaxel is an antineoplastic agent belonging to the taxoid family. It is prepared by semisynthesis beginning with a precursor extracted from the renewable needle biomass of yew plants. The Chemical name for Docetaxel is (2R, 3S)-N-Carboxy-3-Phenylisoserine, N-tert-butylester. 13 ester with 5b-20-epoxy-1, 2a, 4, 7b, 13a-hexahydroxytax-11-en-9-one 4-acetate 2- benzoate, trihydrate.Docetaxel is a white to almost white powder with an empirical formula of C43H53NO1413H2O2 and a molecular weight of 861.9 It is highly lipophilic and practically insoluble in water.

Vinblastine Sulfate for Injection USP is vincaleukoblastine, sulfate (1:1) (salt). It is the salt of an alkaloid extracted from Vinca rosea Linn., a common fl owering herb known as the periwinkle (more properly known as Catharanthus roseus G. Don). Previously, the generic name was vincaleukoblastine, abbreviated VLB. It is a stathmokinetic oncolytic agent. When treated in vitro with this preparation, growing cells are arrested in metaphase. Chemical and physical evidence indicates that vinblastine sulfate has the molecular formula C46H58O9N4H2SO4 and that it is a dimeric alkaloid containing both indole and dihydroindole moieties.

Vincristine Sulfate Injection, USP is the salt of an alkaloid obtained from a common flowering herb, the periwinkle plant (Vinca rosea Linn). Originally known as leurocristine, it has also been referred to as LCR and VCR.The molecular formula for Vincristine Sulfate, USP is C46H56N4O10H2SO4. It has a molecular weight of 923.04.

Pemetrexed disodium heptahydrate has the chemical name L-Glutamine acid, N-[4-[2-(2-amino-4, 7-dihydro-4-oxo1H-pyrrolo[2, 3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate. It is a white to almost-white solid with a molecular formula of C20H19N5Na2O67H2O and a molecular weight of 597.49.

Cytarabine Injection, an antineoplastic, is a sterile isotonic solution for intravenous and subcutaneous use, which contains no preservative and is available in 20 mgmL (1000 mg50 mL) Pharmacy Bulk Package.A Pharmacy Bulk Package is a container of a sterile preparation for parenteral use that contains many single doses. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion.Each mL contains 20 mg Cytarabine, USP and the following inactive ingredients: sodium chloride 0.68% and Water for Injection q.s. When necessary, the pH is adjusted with hydrochloric acid andor sodium hydroxide to a target pH of 7.4. Each vial contains approximately 5.82 mEq sodium

Vinorelbine is asemisynthetic vinca alkaloid, derived from Vinbastine with broad spectrum of antitumor activity. It is a derivative of Vinblastine. However, Vinorelbine may have less neurotoxicity than Vincristine.

Anastroz tablets for oral administration contain 1 mg of Anastrozole, a non steroidal aromatase inhibitor. It is chemically described as 1. 3 Benzenediacetonitrile, a, a, a'. a' tetramethyl-5- (1H- 1 , 2, 4 triazol I yImethyl). Its molecular formula is C I 7 H I 9 N 5

CAPETAZ 500 tablets containing Capecitabine 500mg are Peach colored capsule shaped film coaed tablets. Capecitabine is a fluoropyrimidinecarbamate with antineoplastic activity. It is an orally administered systemic prodrug of 5-deoxy-5-fluorouridine (5DFUR) which is converted to 5-fluorouracil. The chemical name for capecitabine is 5-deoxy-5-fluoro-N-[-(pentyloxy) carbonyl]-cytidine and has a molecular weight of 359.35.

Gefinib is an anlinoquinazoline with the chemical name 4-Quinazolinamine, N-(3-chloro-4 fluorophenyl)-7-methoxy-6(3-4 morpholin)propoxy). Molecular Formula : C22 H24CIFN2O3

Tamoxifen, a nonsteroidal antiestrogen, is a triphenylethylene derivative with both estrogen antagonist on breast tissue and in the CNS and as an estrogen agonist on endometrium, bone and lipids. Tamoxifen and at least several of its metabolites compete with estradiol for binding to cytyplasmic estrogen receptors in tissues such as breast, uterus, vagina, anterior pituitary, and tumors containing high concentrations of estrogen receptors.

Methotrexate (formerly Amethopterin) is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis. Chemically methotrexate is N-[4-[[(2, 4-diamino-6-pteridinyl)methylamino]benzoyl]-L-glutamic acid.

Aprepitant is a substance pneurokinin 1 (NK1) receptor antagonist, chemically described as 5-[[(2 R, 3 S)-2-[(1 r)-1-[3, 5-BIS (TRIFLUOROMETHYL) PHENYL] ETHOXY] -3-(4-fluorophenyl)-4-morpholinyl] methyl]-1, 2-dihydro-3 H-1, 24-triazol-3-one. Its empirical formula is C23H21F7N4O3, and its structural formula is : Aprepitant is a white to off-white crystalline solid, with a molecular weight of 534.43. It is practically insoluble in water. Aprepitant is sparingly soluble in ethanol and isopropyl Clinical Pharmacology.

Temozolomide Capsules for oral administration contain Temozolomide, an imidazotetrazine derivative. The chemical name of Temozolomide is 3, 4-dihydro-3-methyl-4-oxoimidazo[5, 1-d]-as-tetrazine-8-carboxamide.

Imatinib is a small molecule kinase inhibitor. Imatinib mesylate is designated chemically as 4-[(4-Methyl-I-piperazinyl) methyl]-N- [4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl] amino]- phenyl] benzamidemethanesulfonate and its structural formula is

Thalidomide is an immunomodulatory agent with a promising activity against a variety of tumors and cutaneous manifestations of Erythema NodosumLeprosum (ENL). Thalidomide is an off-white to white, nearly odorless, crystalline powder that is soluble at 25C in dimethyl sulfoxide and sparingly soluble in water and ethanol. The glutarimide moiety contains a single asymmetric center and therefore, may exist in either of two optically active forms designated S-(-) or R - (+) Thaildomide is an equal mixture of the S-(-) forms and R-(+) forms and, therefore, has a net optical rotation of zero.

Etoposide, the active ingredient of zuvitop-50 is a semisynthetic derivative of podophyllotoxin used in the treatment of certain neoplastic diseases, . It is available as capsules of 50mg and 100mg.

Fluorouracil injection, an antineoplastic antimetabolite, is a sterile, nonpyrogenic injectable solution for intravenous administration. Each ml contains 50 mg fluorouracil in water for injection, ph is adjusted to approximately 9.2 with sodium hydroxide. Chemically, fluorouracil, a fluorinated pyrimidine, is 5-fluoro-2, 4 (1h, 3h)-pyrimidinedione. It is a white to practically white crystalline powder which is sparingly soluble in water. The molecular weight of fluorouracil is 130.08

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