Uma Brothers

LBS Marg, Mumbai, Maharashtra

SYNONYMS: SODIUM (4-AMINO-1-HYDROXY-1-PHOSPHONOBUTYL)-HYDROXY PHOSPHINATE, TRIHYDRATE –

CAS NUMBER: 129318-43-0 MOL. FORMULA: C4H18NNAO10P2, MOL.WEIGHT: 325.12

ALENDRONATE SODIUM IS A WHITE, CRYSTALLINE .IT IS SOLUBLE IN WATER WITH MELTING RANGE OF 250°C TO 280°C.

STANDARD: OFFERED OF PHARMACEUTICAL GRADE BP/USP/EP – ALENDRONATE SODIUM TRIHYDRATE FORM ALSO AVAILABLE

PACKING: OFFERED IN EXPORT WORTHY PACKING OF 25 KILOS OR AS PER OUR CUSTOMER REQUIREMENTS

SYNONYMS:IBANDRONIC ACID, SODIUM SALT, MONOHYDRATE MOLECULAR

   

FORMULA C9H22O7NP2NA, MOLECULAR WEIGHT 341.21, CAS NUMBER 138926-19-9

IT IS A WHITE-TO OFF-WHITE POWDER. IT IS FREELY SOLUBLE IN WATER AND PRACTICALLY INSOLUBLE IN ORGANIC SOLVENTS. MELTING POINT IS 84° C

STANDARD: OFFERED OF PHARMACEUTICAL GRADE BP/USP/EP

 

PACKING: OFFERED IN EXPORT WORTHY PACKING OF 25 KILOS OR AS PER OUR CUSTOMER REQUIREMENTS

We are offering fosinopril sodium.Fosinopril sodium is a phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat.Fosinopril sodium is the sodium salt of fosinopril, a phosphinic acid-containing angiotensin-converting enzyme (ace) inhibitor with antihyper- tensive activity. Fosinopril sodium is an ester prodrug that is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin ii, resulting in diminished vasopressor activity. In addition, angiotensin ii-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase of serum potassium. synonyms: sodium; (2s, 4s)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxy propoxy)-(4-phenylbutyl) phosphoryl] acetyl] pyrrolidine-2-carboxylatecas number: 88889-14-9, mol. Formula: c30h46nnao7p, mol.weight: 586.65 fosinopril sodium is white to off-white crystalline solid. It is soluble in water (117 mgml at 25 c), dmso (

We are offering mefenamic acid.Mefenamic acid is non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory & antipyretic properties. It is an inhibitor of cyclo- oxygenase. Mefenamic acid is a nonsteroidal anti-inflammatory drug. The mechanism of action of mefenamic acid is as a cyclooxygenase inhibitor. The chemical classification of mefenamic acid is nonsteroidal anti-inflammatory compounds.Mefenamic acid is an anthranilic acid and non-steroidal antiinflammatory drug (nsaid) with anti-inflammatory, antipyretic and analgesic activities. Mefenamic acid inhibits the activity of the enzymes cyclo-oxygenase I and ii, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of mefenamic acid. Mefenamic acid also causes decrease in the formation of thromboxane a2synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. synonyms: 2-(2, 3-dimethylanilino) benzoic acidcas number: 61-68-7, mol. Formula: c15h15no2, mol.weight: 241.29mefenamic acid is a light yellow solid. It is insoluble in water with melting point of 230c. Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

Divalproex sodium is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing gamma-aminobutyric acid levels in the brain or by altering the properties of voltage dependent sodium channels.Divalproex sodium is a stable coordination compound comprised of sodium valproate and valproic acid with anticonvulsant and anti- epileptic activities. Divalproex dissociates to thevalproate ion in the gastrointestinal tract. This agent binds to and inhibits gamma-amino butyric acid (gaba) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of gaba and by inhibiting enzymes that catabolize gaba or block the reuptake of gaba into glia and nerve endings. Divalproex may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. synonyms: sodium; 2-propylpentanoate; 2-propylpentanoic acidcas number: 76584-70-8, mol. Formula: c16h31nao4, mol.weight: 310.4divalproex sodium is a white solid powder. It is soluble in ethanol (95 %), methanol, isopropyl alcohol; partially soluble in water, ether with melting point of 222c.Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

We are offering ibuprofen sodium.Ibuprofen is a nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.Ibuprofen is a propionic acid derivate and nonsteroidal antiinflammatory drug (nsaid) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and ii, resulting in a decreased formation of precursors of prost- aglandins and throm- boxanes. This leads to decreased prostaglandin synthesis, by prost- aglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane a2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. synonyms: 2-[4-(2-methylpropyl) phenyl] propanoic acidcas number: 15687-27-1, mol. Formula: c13h18o2, mol.weight: 206.28ibuprofen is a colourless, crystalline solid. It is readily soluble in most org solvents and very soluble in alcohol with melting range of 75c to 77c.Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

We are offering zoledronic acid anhydrous is a bisphosphonate. The chemical classifi- cation of zoledronic acid anhydrous is diphosphonates anhydrous form of a synthetic imidazole third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix & inhibits farnesyl pyro- phosphate (diphosphate) synthase, thereby preventing protein preny- lation within the mevalonate pathway. This leads to the loss of downs-tream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By pre- venting osteoclast-mediated bone resorption zoledronate decreases bone turnover and stabilizes the bone matrix. synonyms: (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl) phosphonic acidcas number: 118072-93-8, mol. Formula: c5h10n2o7p2, mol.weight: 272.09zoledronic acid is a white solid powder. It is soluble in dmso (0.004 mgml at 25 c), water (

We are offering pravastatin sodium is an antilipemic fungal metabolite isolated from cultures of nocardia autotrophica. It acts as a competitive inhibitor of hmg coa reductase. Pravastatin is the sodium salt of pravastatin with cholesterol-lowering & potential antineoplastic activities. pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme a (hmg-coa) reductase, the enzyme which catalyzes the conversion of hmg-coa to mevalonate, a key step in cholesterol synthesis. This agent lowers plasmacholesterol and lipoprotein levels, and modulates immune responses by suppressing mhc ii (major histocompatibility complex ii) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. In addition, pravastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, & pro-differentiation activities in a variety of tumor cells; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of ras and rho gtpases and related signaling cascades. synonyms: sodium;(3r, 5r)-7-[(1s, 2s, 6s, 8s, 8ar)-6-hydroxy-2-methyl-8-[(2s)-2-methylbutanoyl]oxy-1, 2, 6, 7, 8, 8a-hexahydronaphthalen-1-yl]-3, 5-dihydroxyheptanoatecas number: 81131-70-6, mol. Formula: c23h36nao7, mol.weight: 447.52pravastatin sodium is a white crystalline powder. It is soluble in methanol and water with melting range of 162c to 164c. standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

We are offering valproic acid.Valproic acid is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may be increasing gamma-aminobutyric acid level in brain & by altering the propertie of voltage dependent sodium channels. valproic acid is an anti-epileptic agent and mood stabilizer. The physio- logic effect of valproic acid is by means of decreased central nervous system disorganized electrical activity.Valproic acid is a synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic & antiangiogenesis activities in epilepsy, valproic acidappears to act by increasing the concentration of gamma-aminobutyric acid (gaba) in the brain. This agents antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. synonyms: 2-propylpentanoic acidcas number: 99-66-1, mol. Formula: c8h16o2, mol.weight: 144.21valproic acid is colorless liquid. It is soluble in alcohol and water with melting range of 120c to 130c. standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

We are offering nalidixic acid.Nalidixic acid is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the a subunit of bacterial dna gyrase.Nalidixic acid is a synthetic quinolone and antibacterial agent with urinary tract antiseptic activity. Nalidixic acid concentrates in the renal tubules and bladder and exerts its local antibacterial actions by interference of dna gyrase activity, thereby inhibiting dna synthesis during bacterial replication in a dose-dependent manner. Nalidixic acid is active against most gram-negative organisms that cause urinary tract infections. synonyms: 1-ethyl-7-methyl-4-oxo-1, 8-naphthyridine-3-carboxylic acidcas number: 389-08-2, mol. Formula: c12h12n2o3, mol.weight: 232.24nalidixic acid is a cream-colored powder. It is soluble in chloroform (50 mgml), ethanol (0.9 mgml) at 23 c, methanol (1.3 mgml) at 23 c, toluene (1.6 mgml) at 23 c, dmso ( 6 mgml), and solution of carbonates insoluble in water with melting range of 227c to 229c. standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements

Citicoline is A Nutritional Supplement And Source Of choline and Cytidine With Potential Neuroprotective And Nootropic Activity. citicoline, Also Known As cytidine-5-Diphosphocholine Orcdp-Choline, Is Hydrolyzed Into Cytidine and choline in The Intestine. Following Absorption, Both cytidine And choline are Dispersed, Utilized In Various Biosynthesis Pathways, And Cross The Blood-Brain Barrier For Resynthesis Into citicoline in The Brain Which Is The Rate-Limiting Product In Synthesis Ofphosphatidylcholine.  This Agent Also Increasesacetylcholine (Ach),  norepinephrine (NE) And Dopamine levels In The Central Nervous System (CNS). In Addition, Citicoline is Involved In The Preservation Of Sphingomyelin And Cardiolipin And The Restoration Of Na+/K+-Atpase Activity. citicoline also Increases Glutathione synthesis And glutathione reductase Activity, And Exerts Antiapoptotic Effects.
Citicoline Is A White Solid Powder. It Is Soluble In Water With Melting Range Of 259°C TO 268°C.

We are offering hydroxystearic acid is the saturated counterpart of p-10 acid. Hydroxystearic acid is produced from hydrogenated castor oil (castor wax). Hydroxystearic acids high melting point and hydroxyl bearing chain produce glycerin free gel structures of great strength and workability, the dominant feature of heavy duty greases. The hydroxystearic acid characteristics are utilized in cosmetics, toilet goods, wax blends, polishes, inks and hot melt adhesives. Its reaction with acrylic esters produces hard, durable, thermosetting polymers, which are used in high quality finishes. In coating resins, the hardness, high melting point and reactive hydroxyl group are utilized in both solvent and water- based polymers as well as plasticizer systems. Hydroxystearic acid is also a major component in lithium and calcium based multi - purpose lubricating greases. Hydroxystearic acid also functions as an activator and internal lubricant for natural and synthetic substances. It should be stored away from heat to avoid deterioration. Hydroxystearic acid is insoluble in water and its solubility in many organic solvents is also limited. The hydroxystearic acid we offer is non - toxic. details :appearance : off white/ creamy flakes color gardener : 5 maximumacid value : 175 minimumiodine value : 4 maximumhydroxyl value : 155 minimumsaponification value : 180 minimummelting point : 72-76 degree celsiusmoisture volatile : 0.10% maximumpacking :we are offering 18 tons quantity in a container of 20 feet.

We are offering calamine is either a mixture of zinc oxide (zno) with about 0.5% ferric oxide (fe2o3) or a zinc carbonate compound. It is the main ingredient in calamine lotion and is used as an anti-pruritic (anti-itching agent) to treat conditions such as sunburn, rashes, poison ivy, poison oak, chickenpox, and insect bites and stings. It is also used as a mild antiseptic to prevent infections that can be caused by scratching the affected area, and an astringent to dry weeping or oozing blisters and acne abscesses.
Calamine is a Pink, Odorless, Practically Tasteless, fine Powder. It is Insoluble in Water, Practically Completely Soluble in Mineral Acids with Melting Point of 1975°C.

We are offering para toluene sulfonic acid. we present to you carefully formulated para toluene sulfonic acid. The para toluene sulfonic acid we supply and export is made from extremely pure substances. Thus, our para toluene sulfonic acid is well known for high efficacy. The para toluene sulfonic acid we offer is available at market leading prices. specifications :

• appearance : white needle like crystals
• purity : 95% minimum
• water content : 3.5% maximum
• iron content : 20 ppm maximum
• free sulfuric acid : 1.8% maximum

applications :

• as a hardening agent of furan resin which is applied in foundry industry (sand casting). As catalyst of many resin systems, such as resoles, epoxies, aminoplasts and furniture lacquers
• as intermediate of dye chemistry, adhesives, medical intermediate and specialized plasticizers
• as dehydration catalyst in esterifications, where mineral acids give excess carbonization
• as an anti stress additive for electroplating baths
• it is also used in paint industry

packing :

• offered in 200 kg export worthy barrel or as per our customers choice

We are offering diclofenac sodium is the salt form of diclofenac, an active metabolite of the said aceclofenac (sc - 217557). Hydrolysis of aceclofenac, an inhibitor of interleukin - 1b - induced prostaglandin e2 production with no inhibitory activity against cox (cyclooxy genase), generates diclofenac, which inhibits both cox-1 and cox-2 oxidation of diclofenac produces the metabolite h-hydroxy. Diclofenac demonstrates specific inhibition of cox-2. Inhibition of cox by diclofenac and h-hydroxy diclofenac suppress protaglandin e2 synthesis, producing anti inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (ttr) fibrils, preventing the formation of insoluble amyloidogenic ttr deposits. description :

• cas no. : 15307-79-6
• molecular weight : 318.1
• molecular formula : c14h10cl2no2na
• white solid
• purity : 99%
• solubility : soluble in ethanol dmso or dmf (35mg/ml), soluble in buffers of ionic strength 0.1m and ph 7.2 (9mg/ml)
• boiling point : h12 degree celsius
• boiling point pressure : 203 degree celsius
• melting point : 288 - 290 degree celsius
• vapor pressure : 1.59 e - 07mm hg at 25 degree celsius
• uv absorption : may 285 nm

it is available in different salts such as :

• diclofenac sodium
• diclofenac potassium
• diclofenac diethylammoium
• diclofenac diethylamine, etc.

packing :

• it is available in export worthy drums of 25/50 kilos or as required by our customers

12 HSA is an off-white solid fatty acid used to manufacture lithium and calcium based lubricating greases. When reacted with an ester, 12 HSA provides a hard finish for the automotive and small appliance industries. Production Process:12-Hydroxy Stearic Acid is a waxy hydroxyl fatty acid. The source for the production of 12-hydroxy stearic acid is castor oil which contains up to 85% ricinoleic acid in the form of triglycerides. To produce 12-HSA, castor oil is subjected to hydrogenation, and as a result of it, the ricinoleic acid gets saturated at the place of the double bond and transforms into 12- hydroxyl stearic acid. This process is carried out at room temperature under a pressure of 40 psi with alcohol as a solvent.

ascorbic acid, popularly known as, vitamin c is a water soluble vitamin. Ascorbic acid functions as coenzyme or as a cofactor in the body. Ascorbic acid is necessary for normal function of cellular units and sub cellular structures. In metabolism, ascorbic acid functions to accept and donate hydrogen. Ascorbic acid also plays an important role in the synthesis of neurotransmitters, compounds which allow nerve impulse transmission between nerve axons. Production of collagen, a protein substance in fibrous tissue, depends on ascorbic acid. Vitamin c maintains capillary integrity through the production of intercellular cement substance. This function promotes the healing of wounds fractures, bruises, some hemorrhages and bleeding gum. Additionally, it reduces susceptibility to infections. details :

• molecular formula : c6h806
• case no. : 50-81-7
• einecs no. : 200-066-2
• fema no. : 2109
• h.s. No. : 29362700

benefits :

• ascorbic acid helps to facilitate the absorption of iron and calcium, and it is essential for the utilization of folacin. It is also acts as anti oxidant in the body, which performs very useful functions.
• ascorbic acid supplementation is beneficial for patients suffering from scurvy and its symptoms. Recommended dosages for these patients are 100 mg three times per day, with the alleviation of symptoms usually apparent in 5 days.

packing :

• offered in export worthy packing of 25/50 kilos drums

croscarmellose sodium is internally cross linked sodium carboxy methyl cellulose for use as a disintegrant in pharmaceutical formulations. The cross linking reduces water solubility while still allowing the material to swell and absorb many times its weight in water. As a result, it provides superior drug dissolution and disintegration characteristics, thus improving formulas subsequent bioavailability. Croscarmellose sodium also resolves formulators concerns over long term functional stability, reduced effectiveness at high tablet hardness levels, and similar problems associated with other products. Croscarmellose sodium is developed to enhance drug dissolution. Croscarmellose sodium is a very commonly used, fda approved pharmaceutical additive. Its purpose in most tablets including dietary supplements - is to assist the tablet in disintegrating in the intestinal tract at the required area too slowly, or in the wrong part of the intestine or not at all thereby reducing the efficacy of the active ingredients. Croscarmellose sodium is a stable though hygroscopic material. It should be stored in a well-closed container in a cool & dry place. applications : croscarmellose sodium is used in oral pharmaceutical formulations as a disintegrant for capsules, tablets and granules. In tablet formulations, croscarmellose sodium may be used in both direct compression and wet granulation processes. When used in wet granulations the croscarmellose sodium is best added in both the wet and dry stages of the process (intra and extra granularly), so that the wicking and swelling ability of the disintegrant is best utilized. Concentrations of upto 5% w/w of croscarmellose sodium may be used as a tablet disintegrant although normally 2% w/w is used in tablets prepared by direct compression and 3% w/w in tablets prepared by a wet granulation process. packing : offered in export worthy packing of 25/50 kilos drums

We are offering nicotinic acid. niacin is white crystalline powder and passed through all the tests including solubility, related substances by tlc, assay by titration etc. This is one of the important vitamin which plays very important functions in our body. Niacin is the only b vitamin that can be synthesized in the body from the amino acid tryptophan. In its coenzyme forms, niacin is crucial to energy transfer reactions, particularly the metabolism of glucose, fat, and alcohol. niacin is used for the treatment and prevention of niacin deficiency, for controlling the high cholesterol and triglycerides (types of fat) in the blood & thus reducing the risk of heart attack in people with high cholesterol. Effective sometimes for the treatment coronary artery disease (also called atherosclerosis). Niacin is also available in other multivitamin and nutritional products. It is naturally present in plants and animals, and it is also added to many food items in small amounts as a vitamin supplement. Niacin imporves nervous system functioning.

• niacin (nicotinic acid) is a nutrient additive used in food, feed & pharmaceuticals. It is an essential vitamin of the b group better known as vitamin b3.
• it is important for the release of energy from carbohydates and fats, the metabolism of protein, making certain hormones.
• for enrichment of cereals, flour, rice and dry food preparations for meat and fish curing preparation.
• it reduces ldl (bad) cholesterol and increases hdl (good) cholesterol

specifications :

• product name: niacin (cas no: 59-67-6)
• synonyms: nicotinic acid, vitamin b3
• chemical name: 3 pyridine carboxylic acid
• hs code number 29362920

packing :

• it is offered in export worthy drums of 25/50 kilos

application :niacin is used in pharmaceuticals formulations, dietary food industry, vitamins/ minerals premix, nutritional ingredients, breakfast cereals & many others, infant formulas

We are offering pvp iodine is a stable chemical complex of polyvinylpyrrolidone (pvp) and elemental iodine which is completely soluble in water. Povidone iodine - reddish brown color powder of superior grade passing as per bp/usp grades for use as antiseptic, disinfectant for operation surgical instruments, to treat wounds & burns etc. Povidone iodine offered by us is of international quality and offered in export worthy packs of 25 kilos or as per our customers requirements. This product is made from very high quality of pvp k-30 & iodine with special manufacturing skill. We offer the product in powder form as it is very much convenient for transportation. However, liquid can be made at any time and any place. characteristics of povidone iodine :

• cas no : 25655 - 41 - 8
• chemical formula : (c6h9n0) nl
• molecular weight : 364.95

description : pvp -1 (povidone iodine) is a stable chemical complex of polyvinyl pyrrolidone (pvp) and elemental iodine, which is completely soluble in water, ethanol etc. Pvp- iodine cab extinguish bacterial, virus, fungus, effectively. It is a stable complex with no irritation, which can dissolve in water completely uses : broad - spectrum germicidal action, skin and equipment disinfectant before injection or surgery, anti - infection treatment for oral, surgical, gynecological, skin etc. Disinfects in the foodstuff industry, breeding aquatics also prevents animal diseases. packing : we are offering in 25/50 kg export worthy drums