Product / Services
Post Buy Requirement
Uma Brothers
Uma Brothers
Mumbai, Maharashtra, India
gstGST : 27AGPPS8689E1ZF Verified Add Review
Call 08048783727

Our Products

  1. Anti Hiv Medicines 3 Products available
  2. Catalysts And Absorbents 20 Products available
  3. Pharmaceutical Chemical 10 Products available
  4. Cardiovascular Drugs 3 Products available
  5. Pharmaceuticals Tablets 8 Products available
  6. Medicines Tonics And Drugs 40 Products available
  7. Antihypertensive Drugs 5 Products available
  8. Pharmaceutical Injectables 3 Products available
  9. Antibiotic Drugs 3 Products available
  10. Pharmaceutical Drug 4 Products available
  11. Others 45 Products available

Api Intermediate #126167

Simvastatin

Simvastatin
  • Supplied By UMA Brothers, India
We are offering simvastatin is a derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase (hydroxy methylglutaryl coa reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic ldl receptors, it increases breakdown of ldl cholesterol. Simvastatin is a hmg-coa reductase inhibitor. The mechanism of action of simvastatin is as a hydroxy methylglutaryl-coa reductase inhibitor.Simvastatin is a lipid-lowering agent derived synthetically from a fermentation product of the fungus aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatincompetitively inhibits hepatic hydroxymethyl-glutaryl coenzyme a (hmg-coa) reductase, the enzyme which catalyzes the conversion of hmg-coa to mevalonate, a key step incholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing mhc ii (major histocompatibility complex ii) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. synonyms: [(1s, 3r, 7s, 8s, 8ar)-8-[2-[(2r, 4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3, 7-dimethyl-1, 2, 3, 7, 8, 8a-hexahydronaphthalen-1-yl] 2, 2-dimethylbutanoatecas number: 79902-63-9, mol. Formula: c25h38o5, mol.weight: 418.57simvastatin is a white solid powder. It is soluble in dmso (>25 mgml), ethanol (>25 mgml), water (0.03 mgl), and methanol with melting range of 127c to 132c. standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements
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pharmaceutical intermediates

Pharmaceutical Intermediates
  • Purity 99.9%
  • Packing Offered in Export Worthy Packing
  • CAS NO 61825-94-3
  • CAS NO. 97-63-2
  • Molecular Weight 862.05
  • Nicotinic Acid 59-67-6
  • Moisture 0.2%max
  • Ash content 0.4%max
  • Supplied By UMA Brothers, India

Details

  • 3-amino-4-methylamino-benzoic acid-n-(2-pyridyl)-n-(2- ethoxycarbonylethyl)-amide (212322-56-0)
  • N-(4-cynophenyl)-glycine (42288-26-6)
  • Ethyl 3-(2-((4-cyanophenylamino) methyl)-1-methyl-n- (pyridine-2-yl)-1h-benzo[d]imidazole-5- carboxamido) propanoate (211915-84-3)
  • 2-(n-boc)-aminothiazole-5-carboxylic acid (302964-02-9)
  • 2-amino-n-(2-chloro-6-methylphenyl)thiazole-5-carboxamide (302964-24-5)
  • N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl) amino]-5- thiazole carboxamide (302964-08-5)
  • 4, 6-dichloro-2-methylpyrimidine (1780-26-3)
  • 3-(n-methyl-n-pentyl amino) propionic acid hcl (625120-81-2)
  • Etyl 2-(2-aminothiazol-4-yl) acetate (53266-94-7)
  • 2-amino-4-thiazole acetic acid (29676-71-9)
  • 2-amino-4-thiazole acetic acid hydrochloride (521284-21-9)
  • 2-(4-nitrophenyl) ethanamine hydrochloride (29968-78-3)
  • (r)-2-(4-nitrophenethylamino)-1-phenylethanol hydrochloride (521284-21-9)
  • (r)-2-(4-aminophenethylamino)-1-phenylethanol hcl (521284-22-0)
  • [2-(4-aminophenyl) ethyl] carbamic acid tert-butyl ester (94838-59-2)
  • (r)-4-nitro phenethylamino-(2- hydroxy-2-phenylethyl)-tert-butyl carbamate (223673-35-6)
  • 1, 2, 3, 9-tetrahydro-9-methyl-4(h)-carbazol-4-one (27387-31-1)
  • 3-[(dimethylamino) methyl]-1, 2, 3, 9-tetrahydro-9-methyl-4hcarbazol- 4-one hcl (119812-29-2)
  • 11-(piperazine-1-yl)dienzo[b, f][1, 4]thiazepine hydrochloride (11974-74-4)
  • 3-quinuclidinone hydrochloride (1193-65-3)
  • (3ar, 4s, 6r, 6as)-6-aminotetrahydro-2, 2-dimethyl-4h-cyclopenta-1, 3-dioxol-4-ol(cas 155899-66-4)
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Pimozide

Pimozide
  • Supplied By UMA Brothers, India
We are offering pimozide.Pimozide is a diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. Pimozide is a typical antipsychotic.Pimozide is a diphenylbutylpiperidine derivative & a dopamine antagonist with antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (cns), thereby decreasing dopamine neurotransmission and reducing the occurrence of motor and vocal tics and delusions of parasitosis. In addition, this agent antagonizes alpha-adrenergic and 5-ht2 receptors. synonyms: 3-[1-[4, 4-bis (4-fluorophenyl) butyl] piperidin-4-yl]-1h-benzimidazol-2-onecas number: 2062-78-4, mol. Formula: c28h29f2n3o, mol.weight: 461.55pimozide is a white crystalline powder. It is soluble in dmso (100 mm), and chloroform (25 mg + 5 ml of chcl3) insoluble in water with melting range of 214c to 218c. standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements
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Candesartan

Candesartan
  • Supplied By UMA Brothers, India
We are offering candesartan.Candesartan is an angiotensin 2 receptor blocker. The mechanism of action of candesartan is as an angiotensin 2 receptor antagonist.Candesartan is a synthetic, benzimidazole-derived angiotensin ii receptor antagonist prodrug with antihypertensive activity. candesartan selectively competes with angiotensin ii for the binding of the angiotensin ii receptor subtype 1 (at1) in vascular smooth muscle, blocking angiotensin ii-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of at1 in the adrenal gland inhibits angiotensin ii-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure. synonyms: 2-ethoxy-3-[[4-[2-(2h-tetrazol-5-yl) phenyl] phenyl] methyl] benzimidazole-4-carboxylic acidcas number: 139481-59-7, mol. Formula: c24h20n6o3, mol.weight: 440.45candesartan is a colourless crystalline solid powder. It is soluble in water with melting range of 183cto 185c.Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements
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Pentoxifylline

Pentoxifylline
  • Supplied By UMA Brothers, India
We are offering pentoxifylline is a methylxanthine derivative with hemorrheologic & immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate (camp) in erythrocytes, endothelium & the surrounding tissues. This leads to vasodilation, improves erythrocyte flexibility & enhances blood flow. In addition the increased level of camp in platelets inhibits platelet aggre- gation which may contribute to a reduction in blood viscosity. This agent also inhibits production of tumor necrosis factor-alpha & inter- feron-gamma while it induces th2-like (t-helper 2) cytokine production, thereby inhibiting th1-mediated (t-helper 1) inflammatory & autoimmune responses.Pentoxifylline is a blood viscosity reducer. The physiologic effect of it is by means of hematologic activity alteration. Threfore, methy lxanthine derivative that inhibits phosphodiesterase & affects blood rheology. It improves blood flow by increasing erythrocyte & leukocyte flexibility. It also inhibits platelet aggregation. Pentoxi fylline modulates immunologic activity by stimulating cytokine production. synonyms: 3, 7-dimethyl-1-(5-oxohexyl) purine-2, 6-dionecas number: 6493-05-6, mol. Formula: c13h18n4o3, mol.weight: 278.31pentoxifylline is white to off-white solid powder. It is soluble in water (43 mgml), chloroform, methanol, and benzene with melting range of 104c to 105c. standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements
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Colchicine

Colchicine
  • Supplied By UMA Brothers, India
We are offering colchicine.Colchicine is a major alkaloid from colchicum autumnale l. And found also in other colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial mediterranean fever (periodic disease). The mechanism of action of colchicine is as a cytochrome p450 3a4 inhibitor and p-glycoprotein interaction.Colchicine is an alkaloid isolated from colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines exerts its effect has not been completely established. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This leads to an inhibition of migration of leukocytes and other inflam- matory cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine may also interrupt the cycle of monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response. Overall, colchicine decreases leuko- cyte chemotaxismigration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of uratecrystals. synonyms: n-[(7s)-1, 2, 3, 10 -tetramethoxy-9-oxo-6, 7-dihydro-5h-benzo [a] heptalen-7-yl] acetamidecas number: 64-86-8, mol. Formula: c22h25no6, mol.weight: 399.44colchicine is a pale yellow scales or powder. It is soluble in ethanol (10 mgml), water (45.45 mgml), chloroform, dmso, and methanol with melting range of 142c to 150c.Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements
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Guaifenesin

Guaifenesin
  • Supplied By UMA Brothers, India
We are offering guaifenesin.Guaifenesin is an expectorant that also has some muscle relaxing action. It is used in many cough preparations.Guaifenesin is a glyceryl guaiacolate with expectorant effects. Guaifenesin increases respiratory tract mucus secretions, acts as an irritant to gastric vagal receptors and recruits efferent parasym- pathetic reflexes that cause glandular exocytosis. This agent reduces the viscosity of mucus secretion by reducing adhesiveness and surface tension as well as increasing hydration of mucus.guaifenesin promotes the efficiency of the mucociliary mechanism important in removing accumulated secretions from the upper and lower airway. synonyms: n-[2-[4-(cyclohexylcarbamoylsulfamoyl) phenyl] ethyl]-5-methylpyrazine-2-carboxamidecas number: 93-14-1, mol. Formula: c10h14o4, mol.weight: 198.22guaifenesin is a white crystalline powder. It is soluble in water (50 mgml at 25 c), methanol, dmso (40 mgml at 25 c), dmf, and ethanol (50 mgml) with melting range of 77c to 81c.Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements
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Doxazosin Mesylate

Doxazosin Mesylate
  • Supplied By UMA Brothers, India
We are offering doxazosin mesylate.Doxazosin mesylate is a prazosin-related compound that is a selective alpha-1-adrenergic blocker.Doxazosin mesylate is the mesylate salt form of doxazosin, a quinazoline compound with smooth muscle relaxing activity. Doxazosin mesylate selectively antagonizes alpha-1-adrenergic receptors in smooth muscle of the bladder neck and prostate, thereby relaxing the smooth muscle and decreasing the obstruction and urethral resistance seen with benign prostate hyperplasia (bph). This may improve bph symptoms. This agent also blocks alpha-1-adrenergic receptors in peripheral vascular smooth muscle, which leads to vasodilatation and a subsequent decrease in peripheral vascular resistance. synonyms: [4-(4-amino-6, 7-dimethoxyquinazolin-2-yl) piperazin-1-yl]-(2, 3-dihydro-1, 4-benzodioxin-3-yl) methanone; methanesulfonic acidcas number: 77883-43-3, mol. Formula: c24h29n5o8s, mol.weight: 547.58doxazosin mesylate is a white crystalline powder. It is soluble in water (slihgtly), dmso (15 mgml at 25 c), ethanol (
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Indapamide

Indapamide
  • Supplied By UMA Brothers, India
We are offering indapamide.Indapamide is a benzamide-sulfonamide-indole derived diuretic that functions by inhibiting sodium chloride symporters.Indapamide is an indole derivative of chlorosulphonamide and a sulfamyl diuretic with antihypertensive activity. Indapamide may interact directly with the subunits of delayed rectifierpotassium channels, thereby blocking both slow and rapid k+ (iks and ikr) currents through the channels. Through the homeostasis mechanism in balancing total ion concentration (ca++, na+), it reduces vascular hyperreactivity and peripheral and arterial vascular resistance, possibly by inhibiting transmembrane ionic influx, probably calcium ions, and stimulating prostaglandin e2 synthesis, thereby causing vasodilatation. Indapamide exerts its diuretic effect by inhibiting reabsorption of sodium and chloride, primarily as a result of action on the cortical diluting segment of the renal distal tubule, thereby promoting urinary excretion of water and electrolytes. synonyms: 4-chloro-n-(2-methyl-2, 3-dihydroindol-1-yl)-3-sulfamoyl benzamidecas number: 26807-65-8, mol. Formula: c16h16cln3o3s, mol.weight: 365.83indapamide is a white crystalline solid powder. It is soluble in methanol, dmso (73 mgml at 25 c), ethanol (73 mgml at 25 c), chloroform (slightly), and water (
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Exporter of Api Intermediate from Mumbai, Maharashtra by Uma Brothers
Product / Services
Post Buy Requirement
Uma Brothers

Uma Brothers Mumbai, Maharashtra

Mumbai, Maharashtra, India
gstGST : 27AGPPS8689E1ZF Verified Add Review
Call 08048783727

Our Products

  1. Medicines Tonics And Drugs 40 Products available
  2. Industrial Acid 38 Products available
  3. Catalysts And Absorbents 20 Products available
  4. Drugs 19 Products available
  5. Pharmaceutical Raw Materials 17 Products available
  6. Industrial Chemicals 14 Products available
  7. Pharmaceutical Chemical 10 Products available
  8. Active Pharmaceutical Ingredients 9 Products available
  9. Api Intermediate 9 Products available
  10. Pharmaceuticals Tablets 8 Products available
  11. Others Products 181 Products available

Api Intermediate #126167

We are leaders in the market for providing best range of Simvastatin, Pharmaceutical Intermediates, PIMOZIDE, Candesartan and pentoxifylline

Simvastatin

Simvastatin
  • Supplied By UMA Brothers, India
We are offering simvastatin is a derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase (hydroxy methylglutaryl coa reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic ldl receptors, it increases breakdown of ldl cholesterol. Simvastatin is a hmg-coa reductase inhibitor. The mechanism of action of simvastatin is as a hydroxy methylglutaryl-coa reductase inhibitor.Simvastatin is a lipid-lowering agent derived synthetically from a fermentation product of the fungus aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatincompetitively inhibits hepatic hydroxymethyl-glutaryl coenzyme a (hmg-coa) reductase, the enzyme which catalyzes the conversion of hmg-coa to mevalonate, a key step incholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing mhc ii (major histocompatibility complex ii) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. synonyms: [(1s, 3r, 7s, 8s, 8ar)-8-[2-[(2r, 4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3, 7-dimethyl-1, 2, 3, 7, 8, 8a-hexahydronaphthalen-1-yl] 2, 2-dimethylbutanoatecas number: 79902-63-9, mol. Formula: c25h38o5, mol.weight: 418.57simvastatin is a white solid powder. It is soluble in dmso (>25 mgml), ethanol (>25 mgml), water (0.03 mgl), and methanol with melting range of 127c to 132c. standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements
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pharmaceutical intermediates

Pharmaceutical Intermediates
  • Purity 99.9%
  • Packing Offered in Export Worthy Packing
  • CAS NO 61825-94-3
  • CAS NO. 97-63-2
  • Molecular Weight 862.05
  • Nicotinic Acid 59-67-6
  • Moisture 0.2%max
  • Ash content 0.4%max
  • Supplied By UMA Brothers, India

Details

  • 3-amino-4-methylamino-benzoic acid-n-(2-pyridyl)-n-(2- ethoxycarbonylethyl)-amide (212322-56-0)
  • N-(4-cynophenyl)-glycine (42288-26-6)
  • Ethyl 3-(2-((4-cyanophenylamino) methyl)-1-methyl-n- (pyridine-2-yl)-1h-benzo[d]imidazole-5- carboxamido) propanoate (211915-84-3)
  • 2-(n-boc)-aminothiazole-5-carboxylic acid (302964-02-9)
  • 2-amino-n-(2-chloro-6-methylphenyl)thiazole-5-carboxamide (302964-24-5)
  • N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl) amino]-5- thiazole carboxamide (302964-08-5)
  • 4, 6-dichloro-2-methylpyrimidine (1780-26-3)
  • 3-(n-methyl-n-pentyl amino) propionic acid hcl (625120-81-2)
  • Etyl 2-(2-aminothiazol-4-yl) acetate (53266-94-7)
  • 2-amino-4-thiazole acetic acid (29676-71-9)
  • 2-amino-4-thiazole acetic acid hydrochloride (521284-21-9)
  • 2-(4-nitrophenyl) ethanamine hydrochloride (29968-78-3)
  • (r)-2-(4-nitrophenethylamino)-1-phenylethanol hydrochloride (521284-21-9)
  • (r)-2-(4-aminophenethylamino)-1-phenylethanol hcl (521284-22-0)
  • [2-(4-aminophenyl) ethyl] carbamic acid tert-butyl ester (94838-59-2)
  • (r)-4-nitro phenethylamino-(2- hydroxy-2-phenylethyl)-tert-butyl carbamate (223673-35-6)
  • 1, 2, 3, 9-tetrahydro-9-methyl-4(h)-carbazol-4-one (27387-31-1)
  • 3-[(dimethylamino) methyl]-1, 2, 3, 9-tetrahydro-9-methyl-4hcarbazol- 4-one hcl (119812-29-2)
  • 11-(piperazine-1-yl)dienzo[b, f][1, 4]thiazepine hydrochloride (11974-74-4)
  • 3-quinuclidinone hydrochloride (1193-65-3)
  • (3ar, 4s, 6r, 6as)-6-aminotetrahydro-2, 2-dimethyl-4h-cyclopenta-1, 3-dioxol-4-ol(cas 155899-66-4)
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Pimozide

Pimozide
  • Supplied By UMA Brothers, India
We are offering pimozide.Pimozide is a diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. Pimozide is a typical antipsychotic.Pimozide is a diphenylbutylpiperidine derivative & a dopamine antagonist with antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (cns), thereby decreasing dopamine neurotransmission and reducing the occurrence of motor and vocal tics and delusions of parasitosis. In addition, this agent antagonizes alpha-adrenergic and 5-ht2 receptors. synonyms: 3-[1-[4, 4-bis (4-fluorophenyl) butyl] piperidin-4-yl]-1h-benzimidazol-2-onecas number: 2062-78-4, mol. Formula: c28h29f2n3o, mol.weight: 461.55pimozide is a white crystalline powder. It is soluble in dmso (100 mm), and chloroform (25 mg + 5 ml of chcl3) insoluble in water with melting range of 214c to 218c. standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements
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Candesartan

Candesartan
  • Supplied By UMA Brothers, India
We are offering candesartan.Candesartan is an angiotensin 2 receptor blocker. The mechanism of action of candesartan is as an angiotensin 2 receptor antagonist.Candesartan is a synthetic, benzimidazole-derived angiotensin ii receptor antagonist prodrug with antihypertensive activity. candesartan selectively competes with angiotensin ii for the binding of the angiotensin ii receptor subtype 1 (at1) in vascular smooth muscle, blocking angiotensin ii-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of at1 in the adrenal gland inhibits angiotensin ii-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure. synonyms: 2-ethoxy-3-[[4-[2-(2h-tetrazol-5-yl) phenyl] phenyl] methyl] benzimidazole-4-carboxylic acidcas number: 139481-59-7, mol. Formula: c24h20n6o3, mol.weight: 440.45candesartan is a colourless crystalline solid powder. It is soluble in water with melting range of 183cto 185c.Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements
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Pentoxifylline

Pentoxifylline
  • Supplied By UMA Brothers, India
We are offering pentoxifylline is a methylxanthine derivative with hemorrheologic & immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate (camp) in erythrocytes, endothelium & the surrounding tissues. This leads to vasodilation, improves erythrocyte flexibility & enhances blood flow. In addition the increased level of camp in platelets inhibits platelet aggre- gation which may contribute to a reduction in blood viscosity. This agent also inhibits production of tumor necrosis factor-alpha & inter- feron-gamma while it induces th2-like (t-helper 2) cytokine production, thereby inhibiting th1-mediated (t-helper 1) inflammatory & autoimmune responses.Pentoxifylline is a blood viscosity reducer. The physiologic effect of it is by means of hematologic activity alteration. Threfore, methy lxanthine derivative that inhibits phosphodiesterase & affects blood rheology. It improves blood flow by increasing erythrocyte & leukocyte flexibility. It also inhibits platelet aggregation. Pentoxi fylline modulates immunologic activity by stimulating cytokine production. synonyms: 3, 7-dimethyl-1-(5-oxohexyl) purine-2, 6-dionecas number: 6493-05-6, mol. Formula: c13h18n4o3, mol.weight: 278.31pentoxifylline is white to off-white solid powder. It is soluble in water (43 mgml), chloroform, methanol, and benzene with melting range of 104c to 105c. standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements
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Colchicine

Colchicine
  • Supplied By UMA Brothers, India
We are offering colchicine.Colchicine is a major alkaloid from colchicum autumnale l. And found also in other colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial mediterranean fever (periodic disease). The mechanism of action of colchicine is as a cytochrome p450 3a4 inhibitor and p-glycoprotein interaction.Colchicine is an alkaloid isolated from colchicum autumnale with anti-gout and anti-inflammatory activities. The exact mechanism of action by which colchicines exerts its effect has not been completely established. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This leads to an inhibition of migration of leukocytes and other inflam- matory cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine may also interrupt the cycle of monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response. Overall, colchicine decreases leuko- cyte chemotaxismigration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of uratecrystals. synonyms: n-[(7s)-1, 2, 3, 10 -tetramethoxy-9-oxo-6, 7-dihydro-5h-benzo [a] heptalen-7-yl] acetamidecas number: 64-86-8, mol. Formula: c22h25no6, mol.weight: 399.44colchicine is a pale yellow scales or powder. It is soluble in ethanol (10 mgml), water (45.45 mgml), chloroform, dmso, and methanol with melting range of 142c to 150c.Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements
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Guaifenesin

Guaifenesin
  • Supplied By UMA Brothers, India
We are offering guaifenesin.Guaifenesin is an expectorant that also has some muscle relaxing action. It is used in many cough preparations.Guaifenesin is a glyceryl guaiacolate with expectorant effects. Guaifenesin increases respiratory tract mucus secretions, acts as an irritant to gastric vagal receptors and recruits efferent parasym- pathetic reflexes that cause glandular exocytosis. This agent reduces the viscosity of mucus secretion by reducing adhesiveness and surface tension as well as increasing hydration of mucus.guaifenesin promotes the efficiency of the mucociliary mechanism important in removing accumulated secretions from the upper and lower airway. synonyms: n-[2-[4-(cyclohexylcarbamoylsulfamoyl) phenyl] ethyl]-5-methylpyrazine-2-carboxamidecas number: 93-14-1, mol. Formula: c10h14o4, mol.weight: 198.22guaifenesin is a white crystalline powder. It is soluble in water (50 mgml at 25 c), methanol, dmso (40 mgml at 25 c), dmf, and ethanol (50 mgml) with melting range of 77c to 81c.Standard: offered of pharmaceutical grade bpuspep packing: offered in export worthy packing of 25 kilos or as per our customer requirements
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Doxazosin Mesylate

Doxazosin Mesylate
  • Supplied By UMA Brothers, India
We are offering doxazosin mesylate.Doxazosin mesylate is a prazosin-related compound that is a selective alpha-1-adrenergic blocker.Doxazosin mesylate is the mesylate salt form of doxazosin, a quinazoline compound with smooth muscle relaxing activity. Doxazosin mesylate selectively antagonizes alpha-1-adrenergic receptors in smooth muscle of the bladder neck and prostate, thereby relaxing the smooth muscle and decreasing the obstruction and urethral resistance seen with benign prostate hyperplasia (bph). This may improve bph symptoms. This agent also blocks alpha-1-adrenergic receptors in peripheral vascular smooth muscle, which leads to vasodilatation and a subsequent decrease in peripheral vascular resistance. synonyms: [4-(4-amino-6, 7-dimethoxyquinazolin-2-yl) piperazin-1-yl]-(2, 3-dihydro-1, 4-benzodioxin-3-yl) methanone; methanesulfonic acidcas number: 77883-43-3, mol. Formula: c24h29n5o8s, mol.weight: 547.58doxazosin mesylate is a white crystalline powder. It is soluble in water (slihgtly), dmso (15 mgml at 25 c), ethanol (
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Indapamide

Indapamide
  • Supplied By UMA Brothers, India
We are offering indapamide.Indapamide is a benzamide-sulfonamide-indole derived diuretic that functions by inhibiting sodium chloride symporters.Indapamide is an indole derivative of chlorosulphonamide and a sulfamyl diuretic with antihypertensive activity. Indapamide may interact directly with the subunits of delayed rectifierpotassium channels, thereby blocking both slow and rapid k+ (iks and ikr) currents through the channels. Through the homeostasis mechanism in balancing total ion concentration (ca++, na+), it reduces vascular hyperreactivity and peripheral and arterial vascular resistance, possibly by inhibiting transmembrane ionic influx, probably calcium ions, and stimulating prostaglandin e2 synthesis, thereby causing vasodilatation. Indapamide exerts its diuretic effect by inhibiting reabsorption of sodium and chloride, primarily as a result of action on the cortical diluting segment of the renal distal tubule, thereby promoting urinary excretion of water and electrolytes. synonyms: 4-chloro-n-(2-methyl-2, 3-dihydroindol-1-yl)-3-sulfamoyl benzamidecas number: 26807-65-8, mol. Formula: c16h16cln3o3s, mol.weight: 365.83indapamide is a white crystalline solid powder. It is soluble in methanol, dmso (73 mgml at 25 c), ethanol (73 mgml at 25 c), chloroform (slightly), and water (
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