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Tafluprost is a prostaglandin analogue. This molecule is used topically for controll of advancing open-angle glaucoma and related problems. It is also used for ocular hypertension, alone or in combination with other molecules. It reduces intraocular pressure by increasing the outflow of aqueous fluid from the eyes.
Chemically, tafluprost is a fluorinated analog of prostaglandin f2-alpha. This chemical compound belongs to the class of organic compounds known as prostaglandins and related compounds.
Tafluprost is light yellow to yellow viscous oil with purity more than 99% by hplc. It is freely soluble in ethanol with melting range of 87.5°c. It is practically insoluble in water.
Vardenafil hydrochloride trihydrate is the hydrochloride salt form of vardenafil, a benzenesulfonamide derivative and phosphodiesterase type 5 (pde5) inhibitor with vasodilatory activity.
Vardenafil is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate - specific phosphodiesterase type 5 (pde5). During stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cgmp) in the smooth muscle cells of the corpus cavernosum. The cgmp in turn triggers smooth muscle relaxation, allowing increased blood flow. Therefore, the inhibition of pde5 enhances erectile function by increasing the amount of cgmp.
Iupac name : 2-2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl] phenyl-5-methyl-7-propyl-1h, 4h-imidazo[4, 3-f][1, 2, 4]triazin-4-one trihydrate hydrochloride
Vardenafil hydrochloride trihydrate is white powder with assay more than 99% by hplc (anhydrous substance). It is slightly solube in water, freely soluble in anhydrous ethanol & practicaly insoluble in heptane.
