UMA Brothers

Mumbai, Maharashtra

Paclitaxel is a cyclodecane isolated from the bark of the pacific yew tree, taxus brevifolia. It stabilizes microtubules in their polymerized form leading to cell death. Paclitaxel is a microtubule inhibitor. The physiologic effect of paclitaxel is by means of microtubule inhibition.Paclitaxel is a compound extracted from the pacific yew tree taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein bcl-2 (b-cell leukemia 2).

Pantoprazole Sodium Is The Sodium Salt Of A Substituted Benzimidazole. The Treatment Of Duodenal & Gastric Ulcers, The Prevention Of Gastro-duodenal Damage In Patients Taking Nsaids, And As Adjunctive Therapy With Antibiotics For The Eradication Of Helicobacter Pylori. Intravenous Pantoprazole Is Indicated For The Short Term Treatment Of Gerd, As An Alternative For Those Patients Who Are Unable To Take The Oral Formulation. Other Potential Uses For Intravenous Pantoprazole Include Prevention Of Aspiration Pneumonia In Patients Undergoing Surgery, Prevention Of Stress Ulcers In Intensive Care Patients, Treatment Of Pyloric Channel Ulcers, And Treatment Of Zollinger-ellison Syndrome, It May Also Show Benefit For The Maintenance Treatment Of Erosive Esophagitis It Crosses The Parietal Cell Membrane & Enters The Acidic Parietal Cell Canaliculus Where It Becomes Protonated, Producing The Active Metabolite Sulfenamide, Which Forms An Irreversible Covalent Bond With Two Sites Of The H+/k+-atpase Enzyme Located On Gastric Parietal Cell, Thereby Inhibiting Both Basal And Stimulated Gastric Acid Production. It Relieves Symptoms Such As Heartburn, Difficulty In Swallowing And Persistent Cough. Pantoprazole Belongs To A Class Of Drugs Known As Proton Pump Inhibitors (Ppis)

Details

• Synonyms - Sodium, 5-(Difluoromethoxy)-2-[(3, 4-dimethoxypyridin-2-yl) Methyl Sulfinyl] Benzimidazol-1-ide
• Cas Number - 138786-67-1,
• Mol.Formula - C16h14f2n3nao4s
• Mol. Weight - 405.351
• It Is White To Offwhite Crystalline Powder With Melting Range Of 139°c To 140°c. Miscible (Very Soluble In Phosphate Buffer At Ph 7.4, Practically
• Insoluble In N-hexane) It Is Soluble In Water And Ethanol.
• Standard - Offered Of Pharmaceutical Grade BP/USP/EP
• Packing - Offered In Export Worthy Packing Of 25 Kilos Or As Per Our Customer Requirements.

Salbutamol Is A Medication That Opens Up The Medium And Large Airways In The Lungs. It Is Used To Treat Asthma, Exercise-induced Bronchospasm And Chronic Obstructive Pulmonary Disease (Copd). It May Also Be Used To Treat High Blood Potassium Levels. It Is Usually Used By Nebulizer, Pill, Inhaler, And Intravenous Solution. Albuterol/salbutamol Is Used To Treat Wheezing & Shortness Of Breath Caused By Breathing Problems (Such As Asthma, Chronic Obstructive Pulmonary Disease). It Belongs To Bronchodilators Group. In Vitro Studies And In Vivo Pharmacologic Studies Have Demonstrated That Albuterol Has A Preferential Effect On Beta2-adrenergic Receptors Compared To Isoproterenol. Activation Of Beta2-adrenergic Receptors On Airway Smooth Muscle Leads To The Activation Of Adenylcyclase And To An Increase In The Intracellular Concentration Of Cyclic-3', 5'-adenosine Monophosphate (Cyclic Amp). Increase Of Cyclic Amp Leads To The Activation Of Protein Kinase A, Which Inhibits The Phosphorylation Of Myosin And Lowers Intracellular Ionic Calcium Concentrations, Resulting In Relaxation.

Details

• Synonyms - 4-[2-(Tert-butylamino)-1-hydroxyethyl]-2-(Hydroxymethyl) Phenol; Sulfuric Acid
• Cas Number - 51022-70-9
• Mol. Formula - C26h44n2o10s
• Mol. Weight - 576.70
• It Is White To Off White Crystalline Powder With Melting Range Of 157°cto 158°c. It Is Soluble In Water, And Ethanol
• Standard - Offered Of Pharmaceutical Grade BP/USP/EP
• Packing - Offered In Export Worthy Packing Of 25 Kilos Or As Per Our Customer Requirements.

Domperidone  is a Medication that Acts as Peripherally Selective Antagonist of The dopamine d2 and d3receptors. It is Administered Orally, rectally, Or intravenously. Domperidone is Given in Order to Relieve nausea and vomiting; to Increase the Transit of Food Through The stomach (as A prokinetic agent Through Increase in Gastrointestinal Peristalsis); and to Increase lactation (breast Milk Production) By Release Of prolactin. It is also Used in the Scientific Study of the Way Dopamine (an Important neurotransmitter and hormone) Acts in the Body. The Uses Or indications of Domperidone Vary Between Nations. for Instance, in Italy It is Used in the Treatment Of gastroesophageal Reflux Disease and in Canada, the Drug is Indicated in Upper Gastrointestinal Motility Disorders and to Prevent Gastrointestinal Symptoms Associated with the Use of Dopamine Agonist Antiparkinsonian Agentsdomperidone is a Medicine that Increases the Movements or Contractions of the Stomach and Bowel. Domperidone is also Used to Treat Nausea and Vomiting Caused By other Drugs Used to Treat Parkinson's Disease.

Details

• Synonyms - (z)-but-2-enedioic Acid; 6-chloro-3-[1-[3-(2-oxo-3h-benzimidazol-1-yl) Propyl] Piperidin-4-yl]-1h-benzimidazol-2-one
• Cas Number - 57808-66-9
• Mol. Formula - C22h24cin5o2
• Mol. Weight - 425.91
• It is White Colour Powder with Melting Range of 240-244°c. It is Soluble in Dmso: >10 mg/ml
• Standard - Offered of Pharmaceutical Grade Bp/usp/ep – also Available as Domperidone Maleate
• Packing - Offered in Export Worthy Packing of 25 Kilos or as per Our Customer Requirements.

GLYBURIDE IS AN ANTIDIABETIC SULFONYLUREA DERIVATIVE WITH ACTIONS SIMILAR TO THOSE OF CHLORPROPAMIDE. GLYBURIDE IS A SULFONYLUREA. THE CHEMICAL CLASSIFICATION OF GLYBURIDE IS SULFONYLUREA COMPOUNDS.GLYBURIDE IS A HIGHLY PROTEIN BOUND, LONGER-ACTING SECOND-GENERATION SULFONYLUREA WITH ANTIHYPERGLYCEMIC ACTIVITY. GLYBURIDE, ALSO CALLED GLIBENCLAMIDE, IS MORE LIKELY TO CAUSE HYPOGLYCEMIC EPISODES DUE TO ITS LONGER HALF-LIFE AND POSSIBLE DISPLACEMENT BY OTHER HIGHLY PROTEIN BOUND DRUGS. THIS AGENT IS METABOLIZED INTO TWO INACTIVE METABOLITES WHICH ARE EXCRETED IN THE BILE AND URINE. THIS AGENT SHOWS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPARGAMMA) AGONISTIC ACTIVITY.

Nebivolol hydrochloride is a cardioselective adrenergic beta-1 receptor antagonist (beta-blocker) that functions as a vasodilator through the endothelial l-arginine nitric oxide system. It is used to manage hypertension and chronic heart failure in elderly patients.Nebivolol hydrochloride is the hydrochloride salt preparation of nebivolol (sc-279910), a highly selective antagonist of the 1-ar (1-adrenoceptor) (ki = 0.88 nm, 2-adrenoceptor ki = 48 nm). Nebivolol is described to produce vasodilation through inducing vascular production of no, mediated through nebivolol agonism of the 3-adrenoceptor. Nebivolol demonstrates some affinity at the 1-adrenergic (ki = 1160 nm), sr-1a (serotonin 5-ht1a) (ki = 20 nm) and 5-ht2 (ki = 700 nm), dopamine d2 (ki = 4000 nm), and histamine h1 (ki = 2400 nm) receptors.

Rifampicin is a semisynthetic antibiotic produced from streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of mycobacterium. In susceptible organisms it inhibits dna-dependent rna polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of rna synthesis. Rifampin is bactericidal, and acts on both intracellular & extracellular organismsrifampin is a rifamycin antibacterial. The chemical classification of rifampin is rifamycins. Rifampin is a semisynthetic derivative of rifamycin with broad antibacterial activity. Rifampin inhibits dna-dependent rna polymerase in susceptible bacteria and is often used in combination with other antibiotics for various infections including tuberculosis.

Tolbutamide is a sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide. Tolbutamide is a sulfonylurea. The chemical classification of tolbutamide is sulfonylurea compounds. Tolbutamide is a short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to cause adverse effects, such as jaundice. This agent is rapidly metabolized by cypc29.

Trimetazidine dihydrochloride is a vasodilator used in angina of effort or ischemic heart disease. Trazodone is an antidepressant of the serotonin antagonist and reuptake inhibitor (sari) class. It is a phenylpiperazine compound. Trazodone also has antianxiety (anxiolytic) and sleep-inducing (hypnotic) effects.

Terbutaline is a selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic. Terbutaline is a -adrenoceptor agonist. Terbutaline is an activator of 2-ar.

Lovastatin is a fungal metabolite isolated from cultures of aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme a reductase (hydroxymethyl- glutaryl coa reductases) which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. Lovastatin is a hmg-coa reductase inhibitor. The mechanism of action of lovastatin is as a hydroxymethylglutaryl-coa reductase inhibitor.Lovastatin is a lactone metabolite isolated from the fungus aspergillus terreus with cholesterol-lowering and potential antineoplastic activities lovastatin is hydrolyzed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme a (hmg-coa) reductase, an enzyme involved in cholesterol biosynthesis. In addition, this agent may induce tumor cell apoptosis and inhibit tumor cell invasiveness, possibly by inhibiting protein farnesylation and protein geranylgeranylation, and may arrest cells in the g1 phase of the cell cycle. The latter effect sensitizes tumor cells to the cytotoxic effects of ionizing radiation.