UMA Brothers

Mumbai, Maharashtra

Ticlopidine hydrochloride is an effective inhibitor of platelet aggre- gation commonly used in the placement of stents in coronary arteries. Ticlopidine hydrochloride is the hydrochloride salt form of ticlopidine, a thienopyridine derivative with anticoagulant property. Ticlopidine hydrochloride irreversibly inhibits adenosine-diphosphate (adp)-induced platelet-fibrinogen binding by binding to the glycoprotein (gp) iibiiia complex, one of the two purinergic receptors activated by adp. Inhibition of the receptor activation causes the inhibition of adenylyl cyclase, results in decreased levels of cyclic adenosine monophosphate and thereby interferes with platelet membrane function and subsequent, platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time.

Gemcitabin is A nucleoside Analog used As chemotherapy. gemcitabine is An Anti-cancer ("antineoplastic" or "cytotoxic") Chemotherapy Drug.  Gemcitabine is Classified as An Antimetabolite. Gemcitabin Used for Treating Certain types of Cancer Including Cancers of the Ovary, Lungs Pancreas and Breast. Gemcitabine May Be Used Alone or with Other cancer Medicines. Gemcitabine is An Antimetabolite. It Works By Preventing Certain Proteins from Being Made that are Necessary for Tumor Growth. What Gemcitabine is Used For: Pancreas Cancer, Non-small Cell Lung Cancer, Bladder Cancer, Soft-tissue Sarcoma, Metastatic Breast Cancer, Ovarian Cancer.

Details

• Synonyms - 2', 2' Difluorodeoxycytidine
• Cas Number - 122111-03-9
• Molecular Formula - C9h11f2n3o4 .hcl
• Molecular Weight - 263.2.36.5
• It is White to Off White Crystalline Powder with Melting Range 168.6°c. Soluble in Water, Slightly Soluble in Methanol, Almost Insoluble in  Ethanol or Polar Organic Solvents. also Available as Gemcitabine Elaidate and Gemcitabine Diphosphate
• Standard - Offered of Pharmaceutical Grade BP/USP/EP
• Packing - Offered in Export Worthy Packing or as per Our Customer Requirements.

Memantine Is N-methyl-d-aspartate Receptor Antagonist. The Mechanism Of Action Of Memantine Is As A Nmda Receptor Antagonist.It Treats Moderate To Severe Alzheimer - Type Dementia.  It Works By Blocking Excess Activity Of A Substance In The Brain Called Glutamate. Memantine Is Used To Treat The Symptoms Of Alzheimer's Disease (Ad- A Brain Disease That Slowly Destroys The Memory And The Ability To Think, Learn, Communicate And Handle Daily Activities). Memantine Is In A Class Of Medications Called Nmda Receptor Antagonists. It Works By Decreasing Abnormal Activity In The Brain. Memantine May Improve The Ability To Think And Remember Or May Slow The Loss Of These Abilities In People Who Have Alzheimer's Disease. However, Memantine Will Not Cure Ad Or Prevent The Loss Of These Abilities At Some Time In The Future.

Details

• Synonyms - 3, 5-dimethyladamantan-1-amine; Hydrochloride
• Cas Number - 41100-52-1
• Mol.Formula - C12h22cin
• Mol.weight - 215.77
• Memantine Hydrochloride Occurs As A Fine White To Off-white Powder And Is Soluble In Water And Its Melting Range Is 258 °C
• Standard - Offered Of Pharmaceutical Grade BP/USP/EP
• Packing - Offered In Export Worthy Packing Of 5 Kilos Or As Per Our Customer Requirements.

Ondansetron Hydrochloride Is The Hydrochloride Salt Of The Racemic Form Of Ondansetron, A Carbazole Derivative And A Selective, Competitive Serotonin 5-hydroxytrptamine Type 3 (5-ht3) Receptor Antagonist With Antiemetic Activit. It Is A Competitive Serotonin Type 3 Receptor Antagonist And Is Effective In The Treatment Of Nausea And Vomiting Caused By Cytotoxic Chemotherapy Drugs, Including Cisplatin, And Has Reported Anxiolytic And Neuroleptic Properties. Ondansetron Appears To Competitively Block The Action Ofserotonin At 5ht3 Receptors Peripherally In The Gastrointestinal Tract As Well As Centrally In The Area Postrema Of The Cns, Where The Chemoreceptor Trigger Zone (Ctz) For Vomiting Is Located, Resulting In The Suppression Of Chemotherapy- And Radiotherapy-induced Nausea And Vomiting. This Is Used Alone Or With Other Medications To Prevent Nausea And Vomiting Caused By Cancer Drug Treatment (Chemotherapy) And Radiation Therapy. It Works By Blocking One Of The Body's Natural Substances (Serotonin) That Causes Vomiting. Ondansetron Belongs To A Class Of Medications Called 5-ht3 Blockers.

Details

• Synonyms - 9-methyl-3-[(2-methylimidazol-1-yl) Methyl]-2, 3-dihydro-1h-carbazol-4-one;hydrochloride
• Cas Number - 99614-01-4
• Mol. Formula - C18h20cin3o
• Mol. Weight - 329.82
• Standard - Offered Of Pharmaceutical Grade BP/USP/EP
• Packing - Offered In Export Worthy Packing Of 25 Kilos Or As Per Our Customer Requirements.

Ractopamine Is A Feed Additive To Promote Leanness In Animals Raised For Their Meat. Pharmacologically, It Is A Beta-adrenergic Agonist. It Is The Active Ingredient In Products Known As Paylean For Swine And Optaflexx For Cattle For Use In Food Animals For Growth Promotion. Ractopamine Hydrochloride Is An Adrenergic Β-agonist. Ractopamine Hydrochloride Is An Activator Of Β2-ar And Β1-ar. Ractopamine Hydrochloride Has The Effects Of Increasing Muscle Mass & Decreasing Body Fat In Rodents And Lifestock.

Details

• Synonyms - 4-[3-[[2-hydroxy-2-(4-hydroxyphenyl) Ethyl] Amino] Butyl] Phenol Hydrochloride
• Cas Number - 90274-24-1
• Mol. Formula - C18h24clno3
• Mol. Weight - 337.84
• White Crystalline Powder With Melting Range Of 165°C  To 167°C And Its Soluble In Methanol, Dmso, And Water, Water Solubility
• Standard - Offered Of Pharmaceutical Grade
• Packing - Offered In Export Worthy Packing Of 25 Kilos Or As Per Our Customer Requirements

Fexofenadine is a Non-sedating H1 Histamine Receptor Antagonist. Fexofenadine Hydrochloride, the Active Ingredient is A histamine h1-receptor Antagonist with the Chemical Name (±)-4-[1 Nylmethyl)-1-piperidinyl]-butyl]- Α, Α-dimethylhydroxy-4-benzeneacetic Acid Hydrochloride. Fexofenadine Hcl is the Hydrochloride Salt Form of Fexofenadine, a Carboxylated Metabolic Derivative Of terfenadine and Third Generation Selective histamine h1-receptor Antagonist with Antihistaminic and Non-sedative Effects. fexofenadine competitively Binds Peripheral H1-receptors, Thereby Stabilizing An Inactive Conformation of the Receptor. Consequently histamine binding and Activity as a Result of Mast-cell Degranulation Followed By the Release of Multiple Inflammatory Mediators, such as Interleukins, Prostaglandin and Leukotriene Precursors, is Blocked, Thereby Preventing the Triggering of Pro-inflammatory Pathways.

Details

• Synonyms - 2-(4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl) Piperidin-1-yl) Butyl) Phenyl)- 2-methylpropanoic Acid Hydrochloride
• Cas Number - 153439-40-8
• Molecular Weight - 538.13
• Molecular Formula - C32h40cino4
• Fexofenadine Hydrochloride is a White to Off-white Crystalline Powder with Melting range of 195°C to 197 °C. It is Freely Soluble in Methanol and Ethanol, Slightly Soluble in Chloroform & Water, & Insoluble in Hexane.
• Standard - Offered of Pharmaceutical Grade BP/USP/EP
• Packing - Offered in Export Worthy Packing of 25 Kilos or as per Our Customer Requirements.

Levofloxacin hydrochloride is the hydrochloride salt of levofloxacin (sc-252953), a fluoroquinolone broad spectrum antibiotic with activity against gram-positive and negative bacteria. Levofloxacin is the active s-(-) isomer of the antibacterial agent ofloxacin (sc-219475) and is significantly more efficacious against bacteria than the r-(+) isomer. Levofloxacin & related fluoroquinolones function by inhibiting topo ii (dna gyrase) &topoisomerase iv activity and interrupting dna replication.

Dorzolamide hydrochloride is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions. Distributed throughout many cells and tissues, various carbonic anhydrases play important roles in mineral and metabolic homeostasis.

Venlafaxine hydrochloride is a cyclohexanol and phenylethylamine derivative that functions as a serotonin and noradrenaline reuptake inhibitor (snri) and is used as an antidepressive agent. Venlafaxine hydrochloride is a dual st and slc6a2 (serotonin and noradrenalin re-uptake) inhibitor that displays 30-fold higher affinity for st (sert) (ki = 82 nm) than slc6a2 (net) (ki = 2480 nm).

Betaxolol hydrochloride is a cardioselective beta-1-adrenergic antagonist with no partial agonist activity. Betaxolol hydrochloride is the hydrochloride salt form of betaxolol, a beta-1-selective adrenergic receptor antagonist without intrinsic sympathomimetic activity. Betaxolol hydrochloride acts on the heart and circulatory system and decreases cardiac contractility and rate, thereby reducing cardiac output. When applied topically in the eye, it lowers intraocular pressure by reducing aqueous humor secretion.Betaxolol hydrochloride is a selective 1-ar adrenoceptor antagonist. Adrenoreceptors or adrenergic receptors are g protein-coupled proteins involved in a variety of sympathetic nervous system activities. 1-ar is primarily associated with cardiac output effects.

Triprolidine hydrochloride is a component of cough and cold medicines. It may cause drowsiness. Histamine h1 antagonist used in allergic rhinitis; asthma; and urticaria.

Labetalol hydrochloride is a salicylamide derivative that is a non-cardioselective blocker of beta-adrenergic receptors and alpha-1 adrenergic receptors.Labetalol hydrochloride is the hydrochloride form of labetalol, a third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihyper- tensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting & exercises heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects.

Topotecan hydrochloride is an antineoplastic agent used to treat ovarian cancer. It works by inhibiting dna topoisomerases, type i.Topotecan hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the s phase of the cell cycle, topotecan selectively stabilizes topoisomerase i-dna covalent complexes, inhibiting religation of topoisomerase i-mediated single-strand dna breaks and producing potentially lethal double-strand dna breaks when complexes are encountered by the dna replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the asian tree camptotheca acuminata.

Bromhexine hydrochloride is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine is intended to support the body's mechanisms for clearing mucus from the respiratory tract. This contributes to a secretomotoric effect by helping the cilia transport the phlegm out of the lungs. For this reason it is often added to cough syrups. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as "secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport"

Ambroxol hydrochloride is a metabolite of bromhexine that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride. It is the active ingredient of mucosolvan, mucobrox, mucol, lasolvan, mucoangin, surbronc, ambolar, and lysopain. The substance is a mucoactive drug with several properties including secretolytic and secretomotoric actions that restore the physiological clearance mechanisms of the respiratory tract, which play an important role in the bodys natural defence mechanisms.Ambroxol is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breath.

CYPROHEPTADINE HYDROCHLORIDE IS A SEROTONIN ANTAGONIST AND A HISTAMINE H1 BLOCKER USED AS ANTIPRURITIC, APPETITE STIMULANT, ANTIALLERGIC, AND FOR THE POST-GASTRECTOMY DUMPING SYNDROME, ETC.CYPROHEPTADINE HYDROCHLORIDE IS THE HYDROCHLORIDE SALT OF A SYNTHETIC METHYL-PIPERIDINE DERIVATIVE WITH ANTIHISTAMINIC AND ANTI-SEROTONINERGIC PROPERTIES. CYPROHEPTADINE COMPETES WITH FREE HISTAMINE (HA) FOR BINDING AT HA-RECEPTOR SITES, THEREBY COMPETITIVELY ANTAGONIZING HISTAMINE STIMULATION OF HA-RECEPTORS IN THE GASTROINTESTINAL TRACT, LARGE BLOOD VESSELS, AND BRONCHIAL SMOOTH MUSCLE. THIS AGENT ALSO COMPETES WITH FREE SEROTONIN FOR BINDING AT SEROTONIN RECEPTOR SITES. CYPRO HEPTA DINE EXHIBITS ANTICHOLINERGIC AND SEDATIVE PROPERTIES AND HAS BEEN SHOWN TO STIMULATE APPETITE AND WEIGHT GAIN.

Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase i.irinotecan prevents religation of the dna strand by binding to topoisomerase i-dna complex, and causes double-strand dna breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in october, 2015 (irinotecan liposome injection, trade name onivyde).

Lercanidipine hydrochloride is a calcium channel protein inhibitor which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. It is sold under various commercial names including zanidip. This lowers the blood pressure and allows the heart to work more efficiently.

Moxifloxacin hydrochloride is the hydrochloride salt preparation of moxifloxacin, an 8-methoxy-fluoroquinone compound with broad-spectrum bactericidal activity against gram-positive & gram-negative strains. 8-methoxy-fluoroquinones are described to inhibit the activities of topo ii (dna gyrase) & topoisomerase iv. The 8-methoxy group of moxifloxacin is suggested to confer a lowered propensity for resistance development as compared to other c-8 substituted quinolones, & moxifloxacin demonstrates potent activity against wild-type and first-step gyrase- & topoisomerase iv-resistant mutants. Moxifloxacin shows activity against methicillin-susceptible staphy lococci, penicillin-susceptible and penicillin-resistant pneumococci, penicillin-susceptible & penicillin-resistant viridans group streptococci, group a streptococci, m. Catarrhalis, & h. Influenzae in vitro.

Naphazoline hydrochloride is an adrenergic vasoconstrictor agent used as a decongestant.Naphazoline hydrochloride is the hydrochloride salt form of naphazoline, an imidazole derivative and a direct-acting sympathomimetic amine with vasoconstrictive properties. Upon ocular administration, naphazoline hydrochloride exerts its effect by acting on alpha- adrenergic receptors in the arterioles of the conjunctiva to produce vasoconstriction, resulting in decreased conjunctival congestion and diminished itching, irritation and redness.

Ranitidine hydrochloride is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (h2 receptors). It is used to treat gastrointestinal ulcers.Ranitidine is a medication that decreases stomach acid production. It is commonly used in treatment of peptic ulcer disease, gastroesophageal reflux disease, and zollingerellison syndrome. There is also tentative evidence of benefit for hives. It can be taken by mouth, by injection into a muscle, or into a vein.

Reserpine hydrochloride is an indole alkaloid antipsychotic, & antihypertensive drug that has been used for the control of high blood pressure & for the relief of psychotic symptoms although because of the development of better drugs for these purposes & because of its numerous side- effects, it is rarely used today. The antihypertensive actions of reserpine are a result of its ability to deplete catechola- mines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral vascular resistance. Moreover, reserpine has a peripheral action in many parts of the body, resulting in a preponderance of the effects of thecholinergic part of the autonomous nervous system on the gi tract, smooth muscles, blood vessels, etc.

Sotalol hydrochloride is a compound categorized with class iii antiarrhythmic activity with a mechanism of action that prolongs the action potential and refraction of cardiac tissue through non-selective yet potent -adronergic blocking activity. Sotalol hydrochloride is also considered a non-selective blocker and a potassium channel blocker with an ic50 of 43 m.

Tizanidine hydrochloride is the hydrochloride salt form of tizanidine, an imidazoline derivative structurally similar to clonidine and an adrenergic agonist with muscle relaxant property. Tizanidine stimulates alpha-2 adrenergic receptors in the central nervous system, thereby inhibiting presynaptic release of norepinephrine & increasing the inhibitory effect on alpha motor neurons & motor reflexes. tizanidine exerts some activity at the postsynaptic excitatory amino acid receptors & imidazoline receptors which may contribute to the overall reduction in facilitation of spinal motor neurons. Overall tizanidine hydrochloride causes muscle relaxation reduces spasticity & antinociceptive effects.

Verapamil hydrochloride is a -adrenergic receptor (-ar) antagonist and calcium channel protein inhibitor that blocks the l-type ca2+ channels in smooth and cardiac muscle cells. Verapamil is an anti- arrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adeno- carcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as mdr (p-glycoprotein). Verapamil is a substrate of cyp3a4 and cyp2c6.

Pioglitazone hydrochloride is the hydrochloride salt preparation of pioglitazone, a specific ligand of ppar- (peroxisome proliferator-activated receptor-). Pioglitazone is a thiazolidinedione compound described to produce antiinflammatory and antiarteriosclerotic effects. Pioglitazone is demonstrated to prevent l-name-induced coronary inflammation and arteriosclerosis and to suppress increased tnf- mrna produced by aspirin-induced gastric mucosal injury. Pioglitazone hydrochloride is an activator of ppar .

It Is Sulfonamide Derivative With Adrenergic Antagonist Activity. Tamsulosin Selectivity Binds To And Blocks The Activity Of Alpha1 Adrenoreceptors In The Human Prostate, Prostatic Capsule, Prostatic Urethra & Bladder Neck. Blockade Of These   Adrenoceptors Can Cause Smooth Muscle In The Prostate And Bladder Neck To Relax, Resulting In An Improvement In Urinary Flow Rate. At Least Three Discrete Alpha1-adrenoceptor Subtypes Have Been Identified - Alpha-1a, Alpha-1b And Alpha-1d; Their Distribution Differs Between Human Organs And Tissue. Approximately 70% Of The Alpha1-receptors In Human Prostate Are Of The Alpha-1a Subtype. Tamsulosin Is A Α1 Aadrenergic Receptor Antagonist Used In The Symptomatic Treatment Of Benign Prostatic Hyperplasia (Bph). Tamsulosin Is Used To Improve Urination In Men With Benign Prostatic Hyperplasia (Enlarged Prostate).

Details

• Synonyms - 5-(2-((2-(2-ethoxyphenoxy) Ethyl) Amino) Propyl)-2-methoxy Benzenesulfonamide, Hcl
• Cas Number - 106463-17-6
• Mol. Formula - C20h29cln2o5s
• Mol.wght - 444.97.
• It Is White Crystalline Powder With Melting Range Of 226.1° To 227.8 °c & Slightly Soluble In Ethanol/water & Freely Soluble In Formic Acid.
• Standard - Offered Of Pharmaceutical Grade BP/USP/EP & Pellets
• Packing - Offered In Export Worthy Packing Of 1 Kilo Or As Per Our Customer Requirements.

Terbinafine hydrochloride is a synthetic allylamine derivative structurally related to naftifine, antifungal terbinafine hydrochloride blocks ergosterol biosynthesis by inhibition ofsqualene epoxidase, part of the sterol synthesis pathway for the fungal cell membrane. Highly lipophilic, it tends to accumulate in skin, nails, and fatty tissues. Terbinafine is active against dermatophytes.

Esmolol hydrochloride is the hydrochloride salt form of esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class ii anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta-1 adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation.