Isosorbide Dinitrate, CAS No. : 87-33-2

Isosorbide dinitrate is a vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action. Isosorbide dinitrate is a nitrate vasodilator. The physiologic effect of isosorbide dinitrate is by means of vasodilation. The chemical classification of isosorbide dinitrate is nitrates.
Isosorbide dinitrate is the dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide dinitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (no), which is identical to the endothelium-derived relaxing factor (edrf). No activates guanylyl cyclase, thereby increasing the synthesis of cgmp within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide dinitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area.