Pioglitazone hydrochloride is the hydrochloride salt preparation of pioglitazone, a specific ligand of ppar-γ (peroxisome proliferator-activated receptor-γ). Pioglitazone is a thiazolidinedione compound described to produce antiinflammatory and antiarteriosclerotic effects. Pioglitazone is demonstrated to prevent l-name-induced coronary inflammation and arteriosclerosis and to suppress increased tnf-α mrna produced by aspirin-induced gastric mucosal injury. Pioglitazone hydrochloride is an activator of ppar