Pamidronate Disodium, CAS No. : 57248-88-1

Pamidronate disodium is the disodium salt of the synthetic bisphospho- nate pamidronate. Although it’s mechanism of action is not completely understood, pamidronate appears to adsorb to calcium phosphate crystals in bone, blocking their dissolution by inhibiting osteoclast-mediated bone resorption. This agent does not inhibit bone mineralization and formation.
Pamidronate disodium salt is a bisphosphonate compound, which inhibits farnesyl diphosphate synthase & bone resorption. Studies suggest that pamidronate disodium salt stimulates polymorphonuclear leukocyte and platelet derived nitric oxide production. It is believed that this nitric oxide production can lead to a negative feedback mechanism, which could restrict the inflammatory process and reduce bone resorption. Furthermore, bisphosphonates induce endothelial cell death, cancer cell apoptosis, and nuclear factor-κb pathway activation, via the endothelial protein c receptor.