Listing ID #6280825
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Thiamine plays a very important coenzymatic and non-coenzymatic role in the regulation of basic metabolism. Thiamine diphosphate is a coenzyme of many enzymes, most of which occur in prokaryotes. Pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes as well as transketolase are the examples of thiamine-dependent enzymes present in eukaryotes, including human. Therefore, thiamine is considered as drug or diet supplement which can support the treatment of many pathologies including neurodegenerative and vascular system diseases. On the other hand, thiamine antivitamins, which can interact with thiamine-dependent enzymes impeding their native functions, thiamine transport into the cells or a thiamine diphosphate synthesis, are good propose to drug design. The development of organic chemistry in the last century allowed the synthesis of various thiamine antimetabolites such as amprolium, pyrithiamine, oxythiamine, or 3-deazathiamine. Results of biochemical and theoretical chemistry research show that affinity to thiamine diphosphate-dependent enzymes of these synthetic molecules exceeds the affinity of native coenzyme. Therefore, some of them have already been used in the treatment of coccidiosis (amprolium), other are extensively studied as cytostatics in the treatment of cancer or fungal infections (oxythiamine and pyrithiamine). This review summarizes the current knowledge concerning the synthesis and mechanisms of action of selected thiamine antivitamins and indicates the potential of their practical use.
Adelbert Vegyszerek is a multinational company located in India, has attained leadership status in the manufacturing of poultry & livestock health & feed supplement, and additive raw materials with a dominant position in the intentional market and a significant presence on the global stage with presence in all the major markets worldwide.
We also manufacture & supply animal & poultry feed AMINO ACIDS like Lysine, Methionine, Threonine, Tryptophan, Valine, etc.
Our strong team of suppliers in the International market covers - India, Afghanistan, Algeria, Brazil, Chile, Colombia, Ecuador, El Salvador, Ghana, Iraq, Malaysia, Mexico, Morocco, Myanmar, Nigeria, Panama, Peru, Philippines, Senegal, Spain, Thailand, Tunisia, Turkey, Venezuela, Vietnam, Yemen, etc.
We have state of art dedicated manufacturing facilities for chemicals with identical capacity & manufacturing processes. Our combined manufacturing capacity is in excess of 75000 mt annually. Adelbert vegyszerek is a supplier and exporter of poultry and livestock pharma raw materials.
Our quality assurance wing is supported by an analytical department that ensures adherence to stringent international norms and standards. State-of-the-art instrumentation is used for analysis as well as quality control of all raw materials, intermediates, and final products. The quality department has its own wet lab, instrumentation, and microbiology lab.
Adelbert Vegyszerek meets all tests specifications. We ensure compliance to additional tests over and above the specified to achieve a new benchmark of quality.
Nature of Business
Manufacturer / Exporter / Supplier
Number of Employees
20 - 50
Year of Establishment
2015
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