Trimetazidine dihydrochloride is a vasodilator used in angina of effort or ischemic heart disease. Trazodone is an antidepressant of the serotonin antagonist and reuptake inhibitor (sari) class. It is a phenylpiperazine compound. Trazodone also has antianxiety (anxiolytic) and sleep-inducing (hypnotic) effects.