Topotecan hydrochloride

Listing ID #1709127

We are offering topotecan hydrochloride.
Topotecan hydrochloride is an antineoplastic agent used to treat ovarian cancer. It works by inhibiting dna topoisomerases, type i.
Topotecan hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin with antineoplastic activity. During the s phase of the cell cycle, topotecan selectively stabilizes topoisomerase i-dna covalent complexes, inhibiting religation of topoisomerase i-mediated single-strand dna breaks and producing potentially lethal double-strand dna breaks when complexes are encountered by the dna replication machinery. Camptothecin is a cytotoxic quinoline-based extracted from the asian tree camptotheca acuminata.
synonyms: topotecan monohydrochloride; topotecan hcl; skf-104864a; 9-[(dimethylamino) methyl]-10-hydroxy-(20s)-camptothecin, hcl
cas number: 119413-54-6, mol. Formula: c23h24cln3o5, mol.weight: 457.91
topotecan hydrochloride is white crystalline solid powder. It is
soluble in methanol, water (92 mgml at 25° c), dmso (92 mgml at 25° c), ethanol (