Tocopherols as safe (GRAS) as a nutrient and as preservative (21 CFR, Part 182.8890 & 182.3890) and are GRAS exempt for the requirement for pre-market approval (21 CFR, Part 170.36) for certain food categories. Naturall-e Cosmo Active is TSE & BSE free does not contain any meat or animal derived products, Gluten, Lactose, or Alcohol, and has not been irradiated.