Over the years, there has been an emerging trend in the demand for biopharmaceuticals in the treatment of diseases. Biopharmaceuticals can be produced with microorganisms, adherent cells or suspended....
Over the years, there has been an emerging trend in the demand for biopharmaceuticals in the treatment of diseases. Biopharmaceuticals can be produced with microorganisms, adherent cells or suspended cells. While the recent advances in the technology have paved the way for a more efficient and effective culture of adherent and suspended cells, most bioreactors are only capable of supporting the growth of either adherent cells or suspension cells. The VacciXcellâ„¢ Hybrid Reactor is a laboratory scale bioreactor system that supports both the growth of suspension and adherent cells. It is capable of processing adherent cell culture using macrocarriers or microcarriers, suspension culture and fermentation. It applies the tide motion principle for adherent culture and stir principle for suspension culture. The VacciXcellâ„¢ Hybrid Reactor is ideal for biopharmaceutical companies who are in the initial stages of research and development and are looking to determine the effectiveness, productivity and feasibility of the mammalian cells, whether as suspended or adherent cells.
Principle Adherent Vs. Suspension The interchangeability feature of the matrix vessel and impeller within the reactor vessel allows the reactor to switch its mode from adherent culture to suspension culture. For suspension culture, the suspended cells in the culture medium are stirred using an impeller. On the other hand, adherent cells are cultured by attaching to carriers, BIO Noc™II, which are contained in the matrix vessel. The adherent cells are then alternately exposed to aeration and nutrition as the culture medium moves in and out of the matrix vessel via air pressure. The matrix vessel is cylindrical in shape and perforated halfway. The perforated half is used for medium submersion, while the non-perforated half is used during seeding. The nutrient medium remains at the bottom of the reactor vessel and is kept homogeneous by a built-in magnetic stirrer. Aeration occurs through headspace overlay and through the dissolved oxygen in the nutrient medium.
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Features
Working volume up to 5L for adherent cells and 6.5L for suspension cells
Can run in three modes of operation – batch, fed-batch, and perfusion
Automated monitoring system and various paramaters such as pH, dissolved oxygen, agitation, foaming, temperature, turbidity, biomass, and redox
Four configurable peristaltic pumps for fluid addition
Various impeller designs suited for different microorganisms and suspension cells
Multiple-Use System available at various capacities
No Oxygen limitation during adherent cell culture
Large surface area for adherent cell culture
Tide motion controlled by air pressure
Optional Cleaning-In-Place (CIP) System
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Applications
Protein Production
Vaccine Production
Cell Therapy
Gene Therapy
Antibody production
Research and Development
Company Details
at polytech, we follow our simple road map hire the best technical staff and field engineers, have an honest and positive approach and provide the best value for money to our customers in forms of instruments and services. this coupled with the simple tried and tested formula of timely delivery as well as effective and prompt after sales service is our mantra for success. with the purpose of providing cost effective solutions for scientific instruments as well as laboratory testing instruments backed by industry-leading warranties, our product engineers start with a clear, concise vision laying out your objectives and expectations as well as the resources required to successfully delivering your product. while working on each plan, we communicate frequently with you to keep you updated on the process as well as interact with you to ensure that the product meets your specifications and timely deliveries. to maintain a steadfast focus on qualitative improvements that drives and empowers our presence is the rationalized business policy at polytech. we not only aim and strive to deliver impeccable service - results that are simply faultless - but to collaborate with our customers as their partners in growth and envision our success in their achievements.
Nature of Business Manufacturer / Exporter / Supplier / Trader
Number of EmployeesBelow 20
Year of Establishment2004
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