Temozolomide Capsules

Listing ID #2081466

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Product Details

Temozolomide is an oral alkylating agent used for the treatment of grade iv astrocytoma — an aggressive brain tumor, also known as glioblastoma multiforme — as well as for treating melanoma, a form of skin cancer. Temozolomide is also indicated for relapsed grade iii an plastic astrocytoma and not indicated for, but as of 2011 used to treat oligodendroglioma brain tumors in some countries, replacing the older (and less well tolerated) pcv (procarbazine-lomustine-vincristine) regimen.
temozolomide is a prodrug and animidazotetrazine derivative of the alkylating agent dacarbazine. It has been available in the us since august 1999, and in other countries since the early 2000s.
the therapeutic benefit of temozolomide depends on its ability to alkylate/methylate dna, which most often occurs at the n-7 or o-6 positions ofguanine residues. This methylation damages the dna and triggers the death of tumor cells. However, some tumor cells are able to repair this type of dna damage, and therefore diminish the therapeutic efficacy of temozolomide, by expressing a protein o6-alkylguanine dna alkyltransferase (agt) encoded in humans by the o-6-methylguanine-dna methyltransferase (mgmt) gene. In some tumors, epigenetic silencing of the mgmt gene prevents the synthesis of this enzyme, and as a consequence such tumors are more sensitive to killing by temozolomide. Conversely, the presence of agt protein in brain tumors predicts poor response to temozolomide and these patients receive little benefit from chemotherapy with temozolomide.
dosage form: capsules
strength:
5mg, 20mg, 100mg ,180mg & 250mg
therapeutic category:
• antineoplastic agents
• alkylating1

Company Details

Incorporated in the year 2010, at the pharma hub surat (gujarat, india), we, “actiza pharmaceutical”, are the renowned manufacturer and exporter of an extensive range of anti-cancer drug, anti-malarial drug, anti-hiv medicines, anti-biotics drugs, anti-diabetic drugs, anti-tb, cardiovascular medicines, etc.
our wide range includes anti-protozoal, anthelmintics, dermatology products, erectile dysfunction drugs, etc. The offered range is processed using advanced technology and high quality salts and chemical compounds, which are procured from the reliable and certified vendors of the industry, as per the defined international quality standards. These are extensive demanded for their precise composition, long shelf life, high effectiveness and zero side effects. Our product range is processed using the most advanced machinery under the supervision of skilled professionals. In order to meet the exact requirements of our clients, we offer the entire product range in different customized specifications as per their given details. Moreover, we also offer these at competitive market prices.
we have constructed a state-of-the-art infrastructural unit that is supported with the cutting-edge technologies, which helps us in processing these products in line with set global standards. This infrastructure is comprised of various sub-functional departments in order to ensure smooth flow of the entire business operation. Each unit works in close co-ordination with each other to maintain the business procedures in a smooth manner. Apart from this, our infrastructure unit is followed by our well-equipped latest machineries that enable us to meet the bulk & urgent requirements of the clients. Our adroit team of experts works hard round the clock, in close coordination with clients to meet the varied demands of clients & provide them the products of best quality. To ensure the quality, the entire range of product is stringently tested on various parameters on each and every stage. With the assistance of our hardworking employees, we have been able to cater the diversified needs and requirements of our esteemed clients in the most efficient and effective manner.
in order to maintain a consistent level of quality in our entire product range, we conduct various quality tests on our offered product range. Our offered range is processed in complete conformity with the defined international standards and norms. The entire product range is also tested on various quality parameters using modern testing tools and devices by our skilled quality inspectors in order to ensure their flawlessness. The procured salts and chemical compounds are also subjected to several stringent tests on various parameters to ensure the quality of finished products. We are a customer-centric firm and the main objective of our organization is to achieve the utmost client satisfaction by providing quality products. We deliver our products in a temper-proof packaging material in order to ensure safe transit at the clients' end. Our easy payment modes, transparent dealings, customer-centric approach, competitive price range and ethical business policies make us capable to evolve as the leading name in the industry.