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Contact SupplierSumatriptan is a serotonin agonist that acts selectively at 5ht1 receptors. It is used in the treatment of migraine disorders. Sumatriptan is a serotonin-1b and serotonin-1d receptor agonist. The mechanism of action of sumatriptan is as a serotonin 1b receptor agonist & serotonin 1d receptor agonist.
Sumatriptan is a sulfonamide triptan with vasoconstrictor activity. sumatriptan selectively binds to & activates serotonin 5-ht1d receptors in the central nervous system (cns), thereby constricting cerebral blood vessels. This may lead to a relief in pain from vascular headaches. Sumatriptan may also relieve vascular headaches by decreasing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve.