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Sulphadoxine is a long acting sulfonamide used for the treatment or prevention of malaria. A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.Sulphadoxine is a long acting sulfonamide used for the treatment or prevention of malaria. A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.