Sitagliptin Phosphate

It Is Beta-amino Acid-derived Inhibitor Of Dipeptidyl Peptidase 4 (Ddp-4) With Hypoglycemic Activity. Sitagliptin Phosphate Is A Pyrazine-derived Dipeptidyl-peptidase Iv Inhibitor And Hypoglycemic Agent That Increases The Levels Of The In Cretin Hormones Glucagon-like Peptide-1 (Glp-1) And Glucose-dependent Insulinotropic Polypeptide (Gip). Sitagliptin Is The First In A New Class Of Once Daily, Oral Anti-hyperglycaemic Agents. When Added To Ongoing Metformin Or Pioglitazone Therapy, It Significantly Improved Hba1c In Type-2 Diabetic Patients Who Failed To Achieve Adequate Glycaemic Control With These Agents As Monotherapy And It Was Found To Be Non-inferior To Glipizide When Added To Metformin. This Enzyme-inhibiting Drug Is Used Either Alone Or In Combination With Other Oral Antihyper- Glycemic Agents (Such As Metformin Or A Thiazolidinedione) For Treatment Of Diabetes Mellitus Type 2. The Benefit Of This Medicine Is Its Fewer Side Effects (E.g., Less Hypoglycemia, Less Weight Gain) In The Control Of Blood Glucose Values. While Safety Is Its Advantage, Efficacy Is Often Challenged As It Is Often Recommended To Be Combined With Other Agents Such As Metformin.
Details

• Synonyms - 4 - oxo - 4 - (3 - (Trifluoromethyl) - 5, 6 - dihydro (1, 2, 4) triazolo (4, 3 - a) Pyrazin - 7 (8h) - yl) - 1 - (2, 4, 5 - trifluorophenyl) butan - 2 - amine
• Cas Number - 654671-78-0
• Mol. Formula - C16h15f6n5o H3po4
• Mol. Weight - 505.30
• It is White Colour Crystalline Powder With Melting Range Of 198°C To 202°C And It Is Soluble In Methanol And Water
• Standard - Offered Of Pharmaceutical Grade BP/USP/EP
• Packing - Offered In Export Worthy Packing Of 5 Kilos Or As Per Our Customer Requirements.