Simvastatin

We are offering simvastatin is a derivative of lovastatin and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase (hydroxy methylglutaryl coa reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic ldl receptors, it increases breakdown of ldl cholesterol. Simvastatin is a hmg-coa reductase inhibitor. The mechanism of action of simvastatin is as a hydroxy methylglutaryl-coa reductase inhibitor.
Simvastatin is a lipid-lowering agent derived synthetically from a fermentation product of the fungus aspergillus terreus. Hydrolyzed in vivo to an active metabolite, simvastatincompetitively inhibits hepatic hydroxymethyl-glutaryl coenzyme a (hmg-coa) reductase, the enzyme which catalyzes the conversion of hmg-coa to mevalonate, a key step incholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing mhc ii (major histocompatibility complex ii) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells.
synonyms: [(1s,3r,7s,8s,8ar)-8-[2-[(2r,4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
cas number: 79902-63-9, mol. Formula: c25h38o5, mol.weight: 418.57
simvastatin is a white solid powder. It is soluble in dmso (>25 mgml), ethanol (>25 mgml), water (0.03 mgl), and methanol with melting range of 127°c to 132°c.
standard: offered of pharmaceutical grade bpuspep
packing: offered in export worthy packing of 25 kilos or as per our customer requirements