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Contact SupplierRybelsus tablets (semaglutide) are used for adults with type 2 diabetes mellitus to control blood sugar levels. Rybelsus has also been shown in studies to help weight loss, but it is not an FDA-approved weight loss medicine. Rybelsus tablets are a once-a-day tablet that is used along with diet and exercise. Rybelsus isn't approved as a weight loss aid. Instead, it's used together with healthy eating and exercise habits to manage blood sugar levels in adults with type 2 diabetes.