Topiramate is a sulfamate-substituted monosaccharide with anti- convulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizeskainateampa subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing & decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (gaba) activity & thereby attenuating gabanergic inhibitory transmission.

Topiramate is a sulfamate-substituted monosaccharide with anti- convulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizeskainateampa subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing & decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (gaba) activity & thereby attenuating gabanergic inhibitory transmission.