Listing ID #1708983
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Contact SupplierWe are offering pravastatin sodium is an antilipemic fungal metabolite isolated from cultures of nocardia autotrophica. It acts as a competitive inhibitor of hmg coa reductase. Pravastatin is the sodium salt of pravastatin with cholesterol-lowering & potential antineoplastic activities. pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme a (hmg-coa) reductase, the enzyme which catalyzes the conversion of hmg-coa to mevalonate, a key step in cholesterol synthesis. This agent lowers plasmacholesterol and lipoprotein levels, and modulates immune responses by suppressing mhc ii (major histocompatibility complex ii) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. In addition, pravastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, & pro-differentiation activities in a variety of tumor cells; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of ras and rho gtpases and related signaling cascades.
synonyms: sodium;(3r,5r)-7-[(1s,2s,6s,8s,8ar)-6-hydroxy-2-methyl-8-[(2s)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
cas number: 81131-70-6, mol. Formula: c23h36nao7, mol.weight: 447.52
pravastatin sodium is a white crystalline powder. It is soluble in methanol and water with melting range of 162°c to 164°c.
standard: offered of pharmaceutical grade bpuspep
packing: offered in export worthy packing of 25 kilos or as per our customer requirements