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CAS NO:112529-15-4 Pioglitazone is used along with a proper diet and exercise program to control high blood sugar in patients with type II diabetes. Pioglitazone is a prescription drug of the class thiazolidinedione (TZD) with hypoglycemic (anti hyperglycemic, antidiabetic) action to treat diabetes. It is used to improve glucose control in adults over the age of 18 with type 2 diabetes.