Phosphate Ester The Skydrol 500 series of fluids has the longest service history among phosphate ester products. The first version, Skydrol 500, was introduced in 1952. Steady improvements to the formulation led in 1978 to the current version, Skydrol 500B-4. Skydrol 500B-4 is the most worker friendly of the aviation phosphate esters; it is least irritating to skin and less prone to form mists which can be irritating to the respiratory tract . This has given the product enormous popularity for use in work shops and indoor.