Sildenafil Citrate, CAS No. : 171599-83-0

We are offering Treating Erectile dysfunction in men, high blood pressure in the lungs (pulmonary arterial hypertension [PAH]). It may also be used for other conditions as determined by doctor. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor. It works by relaxing and dilating the blood vessels in the lungs. This lowers the blood pressure in the lungs and helps to improve your ability to exercise. Sildenafil, also used to treat erectile dysfunction and pulmonary arterial hypertension.
It acts by inhibiting cGMP-specific phosphodiesterase type 5 (PDE5), an enzyme that promotes degradation of cGMP, which regulates blood flow in the . It was originally discovered by Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett. Since becoming available in 1998, sildenafil has been a common treatment for erectile dysfunction.
Medical Uses:
1) Sexual dysfunction:-
The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now standard treatment for erectile dysfunction including for those with diabetes mellitus.
2) Pulmonary hypertension:
While sildenafil improves some markers of disease in people with pulmonary arterial hypertension, it does not appear to affect the risk of death or serious side effects as of 2014.
3) Antidepressant-associated sexual dysfunction:
There is tentative evidence that among men who experience antidepressant induced erectile dysfunction sildenafil may help.
4) Altitude sickness:
Sildenafil appears to improve some risk factors for high-altitude pulmonary edema but it is unclear whether or not it affects the rate of the condition itself as of 2008.