Pergolide

Permax (generic name pergolide mesylate) is ergot-derived medication with similarity to parlodel (generic name bromocriptine) and cabergoline (brand name dostinex). Like bromocriptine and cabergoline, pergolide can be used for sexual enhancement, or, more specifically, as support for orgasm.
(the following is pharmacological data from the permax package insert. Please be aware that the dosage information applies to the treatment of parkinson's disease, not for l enhancement. Dosages for are much lower than those for the treatment of parkinson's disease.)
permax (pergolide mesylate) is an ergot derivative dopamine receptor agonist at both d1 and d2receptor sites. Permax is provided for oral administration in tablets containing 0.05 m, 0.25 mg, or 1 mg pergolide as the base.
pergolide mesylate is a potent dopamine receptor agonist. Pergolide is 10 to 1,000 times more potent than bromocriptine on a milligram per milligram basis in various in vitro and in vivo test systems. Pergolide mesylate inhibits the secretion of prolactin in humans; it causes a transient rise in serum concentrations of growth hormone and a decrease in serum concentrations of luteinizing hormone. In parkinson,s disease, pergolide mesylate is believed to exert its therapeutic effect by directly stimulating postsynaptic dopamine receptors in the nigrostriatal system.