Pamidronate Disodium

We are offering pamidronate disodium is the disodium salt of the synthetic bisphospho- nate pamidronate. Although it’s mechanism of action is not completely understood, pamidronate appears to adsorb to calcium phosphate crystals in bone, blocking their dissolution by inhibiting osteoclast-mediated bone resorption. This agent does not inhibit bone mineralization and formation.
Pamidronate disodium salt is a bisphosphonate compound, which inhibits farnesyl diphosphate synthase & bone resorption. Studies suggest that pamidronate disodium salt stimulates polymorphonuclear leukocyte and platelet derived nitric oxide production. It is believed that this nitric oxide production can lead to a negative feedback mechanism, which could restrict the inflammatory process and reduce bone resorption. Furthermore, bisphosphonates induce endothelial cell death, cancer cell apoptosis, and nuclear factor-κb pathway activation, via the endothelial protein c receptor.
synonyms: disodium; [3-amino-1-hydroxy-1-[hydroxy (oxido) phosphoryl] propyl] hydroxyphosphinate; pentahydrate
cas number: 57248-88-1, mol. Formula: c3h9nna2o7p2.xh2o, mol.weight: 279.03
pamidronate disodium is white crystalline powder. It is soluble in water: 28 mgml with melting point of 300°c.
standard: offered of pharmaceutical grade bpuspep
packing: offered in export worthy packing of 25 kilos or as per our customer requirements