Listing ID #1314553
Company Information
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Contact SupplierGeneric Name | Oxaliplatin |
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Brand Name | Megaplat Injection |
Strength Available | 50 MG. and 100 MG. |
Packing | 1 Vial |
Name of Company | Alkem Laboratories Ltd. |
Classification | Platinum analog |
Mechanism of Action |
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Mechanism of Resistance |
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Absorption | Not orally bioavailable. |
Distribution | Widely distributed to all tissues with a 50-fold higher volume of distribution than cisplatin. About 40% of drug is sequestered in red blood cells within 2-5 hours of infusion. Extensively binds to plasma proteins in a time-dependent manner (up to 98%). |
Metabolism | Oxaliplatin undergoes extensive nonenzymatic conÂversion to its active cytotoxic species. As observed with cisplatin, oxaliplatin undergoes aquation reaction in the presence of low concentrations of chloride. The major species are monochloro-DACH, dichloro-DACH, and mono-diaquo-DACH platinum. Renal excretion accounts for> 50% of oxaliplatin clearance. More than 20 different metabolites have been identified in the urine. Only 2% of drug is excreted in feces. Prolonged terminal half-life of up to 240 hours. |
Indications & Usage |
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Dosage Range | Recommended dose is 130 mg/m2 IV over 6 hours, on an every-3-week schedule. Can also give 85 mg/m2 IV over 2 hours, on an every-2-week schedule. |
Drung Preparation |
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Drung Interaction | None known. |
Special Considerations |
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Toxicity |
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