Colistin Colistimethate Sodium 1 MIU Injection (Colistin 1 MIU)

Colistin – Colistimethate sodium for injection and inhalation
Each Injection contains:
Composition:
Colistin Colistimethate sodium injection
Colistin 1 MIU
Each vial contains:
1 Million International Units (1 MIU) Colistimethate Sodium
DOSAGE:
Powder for solution for injection, infusion and inhalation
MODE OF ACTION:
Colistimethate sodium is a cyclic polypeptide antibiotic derived from Bacillus polymyxa var. colistinus and belongs to the polymyxin group. The polymyxin antibiotics are cationic surface-active agents that work by damaging the cell membrane. The resulting physiological effects are lethal to the bacterium. Polymyxins are selective for Gramnegative bacteria that have a hydrophobic outer membrane.
Microbiology
Commonly susceptible species
Acinetobacter species*
Citrobacter species
Escherichia coli
Haemophilus influenzae
Pseudomonas aeruginosa
Species for which acquired resistance may be a problem
Enterobacter species
Klebsiella species
Inherently resistant organisms
Brucella species
Burkholderia cepacia and related species
Neisseria species
Proteus species
Providencia species
Serratia species
Anaerobes
All Gram-positive organisms
*In vitro results may not correlate with clinical responses in the case of Acinetobacter species.
When necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of the agent in at least some types of infections is questionable.
Cross-resistance
Cross-resistance between colistimethate sodium and polymyxin B would be expected. Since the mechanism of action of the polymyxins is different from that of other antibiotics, resistance to colistin and polymyxin by the above mechanism alone would not be expected to result in resistance to other drug classes.
DOSAGE AND METHOD OF ADMINISTRATION
Systemic Treatment
Colistin can be given as a 50 mL intravenous infusion over a period of 30 minutes. Patients with a totally implantable venous access device (TIVAD) in place may tolerate.