Olanzapine

We are offering olanzapine.
Olanzapine is an atypical antipsychotic. Olanzapine is a synthetic derivative of thienobenzodiazepine with antipsychotic, antinausea & antiemetic activities. As a selective monoaminergic antagonist, olanza- pine binds with high affinity binding to the following receptors: seroton- inergic, dopaminergic, muscarinic m1-5, histamine h1, and alpha-1-adre- nergic receptors; it binds weakly to gamma-aminobutyric acid type a, benzodiazepine & beta-adrenergic receptors. The antinausea & antiemetic effects of this agent appear to be due to the blockade of 5-ht2 and 5-ht3 receptors for serotonin. Although its exact mechanism of action in schiz ophrenia is unknown it has been proposed that olanzapine antipsychotic activity is mediated through antagonism to dopamine d2 recep- tors with rapid ligand-receptor dissociation kinetics that help to minimize extrapyramidal symptoms. Olanzapine may also stimulate appetite.
synonyms: 2-methyl-4-(4-methylpiperazin-1-yl)-5h- thieno [3, 2-c] [1, 5] benzodiazepine
cas number: 132539-06-1, mol. Formula: c17h20n4s, mol.weight: 312.43
olanzapine is yellow crystalline powder. It is soluble in water, 39.88 mgl at 25 deg c (est) practically insoluble in water with melting point of 195°c.
standard: offered of pharmaceutical grade bpuspep
packing: offered in export worthy packing of 25 kilos or as per our customer requirements