Tizanidine Hydrochloride, CAS No. : 64461-82-1

Tizanidine hydrochloride is the hydrochloride salt form of tizanidine, an imidazoline derivative structurally similar to clonidine and an adrenergic agonist with muscle relaxant property. Tizanidine stimulates alpha-2 adrenergic receptors in the central nervous system, thereby inhibiting presynaptic release of norepinephrine & increasing the inhibitory effect on alpha motor neurons & motor reflexes. tizanidine exerts some activity at the postsynaptic excitatory amino acid receptors & imidazoline receptors which may contribute to the overall reduction in facilitation of spinal motor neurons. Overall tizanidine hydrochloride causes muscle relaxation reduces spasticity & antinociceptive effects.