Piroxicam, CAS No. : 36322-90-4

Piroxicam is a cyclooxygenase inhibiting, non-steroidal antiinflammatory agent (nsaid) that is well established in treating rheumatoid arthritis and osteoarthritis & used for musculoskeletal disorders dysmenorrhea and postoperative pain. Its long half-life enables it to be administered once daily. It is a nonsteroidal antiinflammatory drug. The mechanism action of piroxicam is as a cyclooxygenase inhibitor. The chemical classi- fication of piroxicam is nonsteroidal antiinflammatory compounds.
Piroxicam is a nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (nsaid),piroxicam binds and chelates both isoforms of cyclooxygenases (cox1 and cox2), thereby stalling phospholipase a2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects.