Nimodipine

Nimodipine is a calcium channel blockader with preferential cerebro vascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
Nimodipine is a 1, 4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated l-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction & subsequent vasoconstriction. compared to other calcium channel blocking agents, nimodipine exhibits greater effects on cerebral circulation than on peripheral circulation. nimodipine is used to as an adjunct to improve the neurologic outcome following subarachnoid hemorrhage from ruptured intracranial aneurysm.