Nebivolol Hydrochloride

Nebivolol hydrochloride is a cardioselective adrenergic beta-1 receptor antagonist (beta-blocker) that functions as a vasodilator through the endothelial l-arginine nitric oxide system. It is used to manage hypertension and chronic heart failure in elderly patients.
Nebivolol hydrochloride is the hydrochloride salt preparation of nebivolol (sc-279910), a highly selective antagonist of the β1-ar (β1-adrenoceptor) (ki = 0.88 nm, β2-adrenoceptor ki = 48 nm). Nebivolol is described to produce vasodilation through inducing vascular production of no, mediated through nebivolol agonism of the β3-adrenoceptor. Nebivolol demonstrates some affinity at the α1-adrenergic (ki = 1160 nm), sr-1a (serotonin 5-ht1a) (ki = 20 nm) and 5-ht2 (ki = 700 nm), dopamine d2 (ki = 4000 nm), and histamine h1 (ki = 2400 nm) receptors.