Moxifloxacin Hydrochloride

Moxifloxacin hydrochloride is the hydrochloride salt preparation of moxifloxacin, an 8-methoxy-fluoroquinone compound with broad-spectrum bactericidal activity against gram-positive & gram-negative strains. 8-methoxy-fluoroquinones are described to inhibit the activities of topo ii (dna gyrase) & topoisomerase iv. The 8-methoxy group of moxifloxacin is suggested to confer a lowered propensity for resistance development as compared to other c-8 substituted quinolones, & moxifloxacin demonstrates potent activity against wild-type and first-step gyrase- & topoisomerase iv-resistant mutants. Moxifloxacin shows activity against methicillin-susceptible staphy lococci, penicillin-susceptible and penicillin-resistant pneumococci, penicillin-susceptible & penicillin-resistant viridans group streptococci, group a streptococci, m. Catarrhalis, & h. Influenzae in vitro.