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Contact Suppliereuphoriamodafinil is effective at crossing the blood-brain barrier, at which point it enters the central nervous system. After entering the central nervous system, it acts on the dopamine transporter and inhibits the reuptake of dopamine. Dopamine is the “feel-good” neurotransmitter that gets activated when we eat good food, have sex, or exercise. Some people claim this is why modafinil increases their motivation.modafinil and modalert have been shown to influence histamine levels in the brain. This can promote increased wakefulness during the day and is the primary effect of modalert.