Metformin Hydrochloride Sr Glimipiride Tablets For Clinical, Hospital

Novimet G1/G2 Tablets

Metformin 500 mg + Glimepiride tablets are a combination medication used to manage type 2 diabetes mellitus. This formulation combines two antidiabetic agents: **Metformin**, which belongs to the class of biguanides, and **Glimepiride**, a sulfonylurea.

### **Metformin (500 mg)**:

- **Mechanism**: Lowers blood sugar levels by improving insulin sensitivity, reducing hepatic glucose production, and increasing glucose uptake by muscle cells.

- **Function**: Primarily targets insulin resistance and helps in reducing fasting and postprandial blood glucose levels.

### **Glimepiride**:

- **Mechanism**: Stimulates the pancreas to produce more insulin by enhancing the release of insulin from pancreatic beta cells.

- **Function**: Helps in managing blood sugar levels, particularly by addressing insufficient insulin production.

### **Usage**:

- **Indication**: Primarily prescribed for patients with type 2 diabetes who cannot manage their blood sugar levels adequately through diet and exercise alone. 

- **Administration**: Usually taken once or twice daily with meals to reduce the risk of gastrointestinal upset and to enhance absorption.

### **Precautions**:

- **Monitoring**: Regular monitoring of blood sugar levels is necessary to avoid hypoglycemia or hyperglycemia.

- **Side Effects**: Common side effects include gastrointestinal disturbances (nausea, diarrhea), hypoglycemia (especially with improper dosing), and potential allergic reactions. Long-term use of metformin may also affect vitamin B12 levels.

This combination helps to improve overall glycemic control by targeting both insulin resistance (via Metformin) and pancreatic insulin production (via Glimepiride), making it an effective therapy for managing type 2 diabetes.