METHANDIENONE binds to and activates the androgen receptor (AR) in order to exert its effects. These include dramatic increases in protein synthesis, glycogenolysis, and muscle strength over a short space of time. Side effects such as gynecomastia, high blood pressure, acne and male pattern baldness may begin to occur. The drug causes severe masculinizing effects in women even at low doses. In addition, it is metabolized into methylestradiol by aromatase. This means that without the administration of aromatase inhibitors such as anastrozole or aminoglutethimide, estrogenic effects like gynecomastia (breast development) may appear over time in men. Many users combat the estrogenic side effects with anastrozole, tamoxifen or clomifene. In addition, as with other 17α-alkylated steroids, the use of metandienone over extended periods of time can result in liver damage without appropriate precautions.

METHANDIENONE binds to and activates the androgen receptor (AR) in order to exert its effects. These include dramatic increases in protein synthesis, glycogenolysis, and muscle strength over a short space of time. Side effects such as gynecomastia, high blood pressure, acne and male pattern baldness may begin to occur. The drug causes severe masculinizing effects in women even at low doses. In addition, it is metabolized into methylestradiol by aromatase. This means that without the administration of aromatase inhibitors such as anastrozole or aminoglutethimide, estrogenic effects like gynecomastia (breast development) may appear over time in men. Many users combat the estrogenic side effects with anastrozole, tamoxifen or clomifene. In addition, as with other 17α-alkylated steroids, the use of metandienone over extended periods of time can result in liver damage without appropriate precautions.