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uses:megaparin is used to prevent deep venous thrombosis, a condition in which harmful blood clots form in the blood vessels of the legs. these blood clots can travel to the lungs and can become lodged in the blood vessels of the lungs, causing a condition called pulmonary embolism. megaparin is used for several days after hip or knee replacement surgery, and in some cases following abdominal surgery, while you are unable to walk. it is during this time that blood clots are most likely to form. megaparin is also used if you are unable to get out of bed because of a serious illness. in addition, megaparin is used to prevent blood clots from forming in the arteries of the heart during certain types of chest pain and heart attacks.