Levofloxacin hydrochloride is the hydrochloride salt of levofloxacin (sc-252953), a fluoroquinolone broad spectrum antibiotic with activity against gram-positive and negative bacteria. Levofloxacin is the active s-(-) isomer of the antibacterial agent ofloxacin (sc-219475) and is significantly more efficacious against bacteria than the r-(+) isomer. Levofloxacin & related fluoroquinolones function by inhibiting topo ii (dna gyrase) &topoisomerase iv activity and interrupting dna replication.