This modular system with very sturdy all-metal construction and rotatable operational bit, fitting various types of clips is suitable for the laparoscopic application of ligatures. It consists of the handle, the shaft and the clip applicator insert, and it may be easily and swiftly dismantled for cleaning purposes. The applicator insert can easily be exchanged for an insert with different bit. The instruments are rotatable, and they can be assembled and dismantled without tools.