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Oral Jelly 100mg contains sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor. Sildenafil Sildenafil in Oral Jelly acts on the erectile tissue of the to increase blood flow into the , which is needed to cause an erection. During sexual stimulation nitric oxide is released in the erectile tissue of the which activates the enzyme guanylate cyclase. This enzyme increases levels of a chemical called cyclic guanosine monophosphate (cGMP), which relaxes the blood vessels in the and allows blood to fill the spongy erectile tissues to cause an erection. Another enzyme called phosphodiesterase type 5 (PDE5) breaks down cGMP preventing blood flow into the , which causes loss of an erection. Sildenafil in Oral Jelly inhibits the action of PDE5 which resolves erectile dysfunction by allowing the natural process of sexual stimulation to activate the cGMP mechanism for achieving and maintaining an erection. Oral Jelly is faster acting that in tablet form as it is absorbed into the blood more rapidly, being effective with 20-45 minutes.