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citrullus colocynthis is a medicinal plant traditionally used as an abortifacient and to treat constipation, oedema, bacterial infections, cancer and diabetes. This plant is used as anticancer agent in many drugs. It is useful in biliousness, fever, intestinal parasites, constipation, hepatic and abdominal, visceral and cerebral congestions, dropsy, etc. Juice of the fruit mixed with sugar is a house-hold remedy in dropsy. Root is useful in jaundice. Root is given in abdominal enlargements and in coughs and asthmatics attacks of children. For intestinal inflammation, tumors etc. The powder of this root is given. In many traditional plants such as the citrullus colocynthis are used as anti-diabetic remedies. Oral administration of the plant extract reduced the plasma level of ast and ldh significantly. However, the plant extract failed to reduce the increased blood level of ggt and alp in diabetic rats. Methanolic fruit extract of c. Colocynthis was screened to evaluate its free-radical scavenging effect. The good antioxidant and free radical scavenging ability of the fruit extract was observed