Indinavir is a potent and specific hiv protease inhibitor that appears to have good oral bioavailability.indinavir anhydrous is a protease inhibitor. The mechanism of action of indinavir anhydrous is as a hiv protease inhibitor. Indinavir anhydrous is an anhydrous formulation of indinavir, a synthetic hydroxyaminopentane amide agent that selectively inhibits the protease of both human immunodeficiency virus 1 and 2. The incorporation of a basic amine into the hydroxyethylene backbone improves its aqueous solubility and its oral bioavailability.