The proposed reactor was competitively priced and met our technical specifications. For Novan, the materials of construction (Hastelloy®), minimalization of dead volumes, pressure temperature ratings, and vessel capacity were the most critical requirements. Advantages of Büchi include responsiveness of the local distribution partner, transparency during the equipment build in Europe, and effective installationtrouble shooting. Novan is very satisfied with the Büchi high pressure reactor and, in fact, we ordered a second unit during