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Estramustine Phosphate Capsules BP 140 mg is used in palliative therapy of metastatic or progressive prostate cancer. Estramustine appears to act as a relatively weak alkylating agent and imparts a weak estrogenic activity. The estrogenic portion of the molecule acts as a carrier to facilitate selective uptake of the drug into estrogen receptor-positive cells. Because of the selective steroidal uptake, the alkylating effect of the nitrogen mustard is enhanced in these cells. Estramustine phosphate is readily dephosphorylated during absorption, and the major metabolites in plasma are estramustine, the estrone analog, estradiol, and estrone.
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3s corporation is Supplier,Exporter ,Wholesaler for Estramustine Phosphate Capsules BP 140 mg in India.
ADDITIONAL INFORMATION
Dose in Prostate Cancer
Adults
14 mg/kg/day (range, 10 to 16 mg/kg/day) in 3 to 4 divided doses for 30 to 90 days before assessing for continuation of therapy. Continue therapy as long as response is favorable.
GENERAL ADVICEAdminister with water 1 h or more before or 2 h after meals.
SIDE EFFECTS
Hypertension; CHF; edema; increased risk of cerebrovascular accident; MI, thrombosis.
CNSLethargy; emotional lability; insomnia.
DERMATOLOGICRash; pruritus; dry skin; easy bruising.
ENDOCRINEDecreased glucose tolerance; breast tenderness or enlargement.
GINausea; vomiting; diarrhea; anorexia; flatulence; elevated LFTs.
GENITOURINARYDecreased glucose tolerance; gonadal suppression; breast tenderness; breast enlargement.
HEMATOLOGICLeukopenia and thrombocytopenia have been reported in a small number of patients.
MUSCULOSKELETALLeg cramps.
RESPIRATORYDyspnea.
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