Apollo Life Sciences Doxorubicin Injection

Category: Anticancer MANUFACTURER
Each vial contains:-
Doxorubicin….. 10mg and 50mg
Quality Specification:
Chromatographic Purity: NLT 99.5%

It is a antitumour antibiotic and finds a useful application in acute leukemia & in many solid tumours. Doxorubicin is capable of cusing breaks in DNA strands and have mutagenic and carcinogenic potential. Maximum action is exerted at S phase, but toxicity is usually exhibited in G2 phase.
Composition : 10mg/5ml, 50mg/25ml
Indication : Malignant lymphoma. Gastro-intestinal tract carcinoma. Bronchogenic, bladder, breast & overian carcinoma. Wilm’s tumour. Acute my eloblastic leukaemia. Soft tissue & bone sarcomas.
Dosage :- 1.2-2.4 mg/kg body wt or 60-75 mg/sq metre of body surface given as a single dose every 3 week by slow i.v. inj.
Contra Indications :- Cardiac disease. Hepatic dysfunction.
Special Precautions :- ECG changes, arrhythmias, hypotension, or be delayed congestive heart failure.
Paediatrics : Reduced dose necessary.
Pregnancy :- Not usually prescribed.
Lactation :- Not prescribed.
Elderly :- Reduced dose may be necessary.
Side Effects :- Cardiotoxicity, alopecia, Bone marrow depression, alopecia, cardiomyopathy, stomatitis, vomiting and local tissue damage.
Drug Interactions :- Cyclosporin, cardiotoxic agents potentiates the cardiotoxicity.
Purity : Not less than 99%.

Facility - WHO-GMP