Cyproheptadine Hydrochloride is a serotonin and histamine antagonist with anticholinergic and sedative property. It finds clinical application in stimulating the appetite and growth. The appetite stimulating effect of Cyproheptadine is probably a consequence of serotonin antagonism. It antagonizes the satiety stimulating effects of serotonin on the satiety center. When stomach is empty, sugar level decreases sending signals to the brain activating appetite center