Cefixime is a third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases. Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime.the antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.