Listing ID #2058963
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Category: Anticancer
Each vial contains:-
Carboplatin….. 150mg ,450 mg and 600 mg
Quality Specification:
Chromatographic Purity: NLT 99.5%
It is a platinum coordination complex. It causes cross linking of DNA; favoured site being N7 of guanine residue. It can also react with –SH groups in proteins and has radiomimetic property. It is bound to plasma proteins, enters, tissues & is slowly excreted unchanged in urine. Cisplatin is very effective in metastatic testicular & ovarian carcinoma. It has found use in some other solid tumours as well.
Composition : 150mg,/15ml, 450mg/45ml
Indication : Metastatic testicular and overian carcinoma, advanced bladder, Head & neck cancer.
Dosage :- Admin by slow infusion 10-60 mg or as required.
Contra Indications :- Pregnancy, lactation hypersensitivity, renal impairment.
Special Precautions :- Maintain good hydration. Shock like state sometimes occurs during i.v. infusion,. Monitor haematological, neurological status & renal functions. Hypomagnesaemia. Hypocalcaemia. Hyperuricaemia.
Paediatrics : Not usually prescribed. The risk of hearing loss is increased.
Pregnancy :- Not usually prescribed.
Lactation :- Not advised.
Elderly :- Reduced dose may be necessary.
Side Effects :- Nausea, vomiting, Tinnitus, deafness, neuropathy, nephrotoxicity, electrolyte imbalance.
Drug Interactions :- Potentiates neurotoxicity with aminoglycosides. Ideal combination with other cytotoxic drugs. Synergistic with 5-fluorouracil and etoposide.
Purity : Not less than 99%.
Facility - WHO-GMP
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